Number of supernumerary vitrified blastocysts is positively correlated with implantation and live birth in single-blastocyst embryo transfers

Abstract

Objective To estimate if live birth in single blastocyst transfers is correlated with the number of sibling supernumerary vitrified blastocysts (embryos not transferred) generated from that same cycle. Design Retrospective cohort study. Setting A large academic ART clinic. Patients All single blastocyst transfers in 2010 of a SART grade ‘good’ embryo. Interventions None. Main Outcome Measures Implantation and live birth. Results 655 single blastocyst transfers met inclusion criteria. Implantation occurred in 65% and live birth in 54% of cycles. In chi-square analysis, patients with supernumerary vitrified blastocysts had statistically higher implantation rate (65% versus 50%) and live birth rate (56% versus 41%) when compared to patients without supernumerary blastocysts. Univariate logistic regression demonstrated an increase in implantation (OR 1.09, 95%CI 1.03–1.15) and live birth (OR 1.06, 95%CI 1.02–1.09) with increasing number of supernumerary blastocysts. Multivariate logistic regression analysis demonstrated patient age and the number of supernumerary blastocysts to be significantly associated with implantation and live birth. Conclusion The number of supernumerary vitrified blastocyst correlated positively with the odds of implantation and live birth in good quality single blastocyst transfers. Patients with supernumerary blastocysts are good candidates for single embryo transfer.

National trends and outcomes of autologous in vitro fertilization cycles among women ages 40 years and older

“…There are other variables aside from maternal age that were associated with positive outcomes. Some are intuitive and consistent with prior literature in older women, including the retrieval of more oocytes [5,9,20], the transfer of more embryos [4,6,21] at a more advanced embryonic stage, and the cryopreservation of more supernumerary embryos [22]. Similar to what has been seen previously [23], our study found that a lower gonadotropin dose was associated with higher rates of clinical pregnancy and live birth in the multivariable analysis.…”

Timing luteal support in assisted reproductive technology: a systematic review

“…One study reported a statistical difference in the number of supernumerary embryos for freezing between the two randomized groups (Day 3 progesterone group: 1.3 embryos for freezing versus Day 6 progesterone group: 2.7 embryos for freezing, P =0.01) (20). Supernumerary embryos have been associated with an increased likelihood of pregnancy (24). …”

Extremities of body mass index and their association with pregnancy outcomes in women undergoing in vitro fertilization in the United States

“…Our study is limited by its cycle-based rather than patient-based nature, by the lack of some patient medical information such as tobacco use, nonfertility-related medical history, obstetric complications, interpregnancy interval, pregnancy weight gain, and the lack of embryo quality data. To minimize the effects of lack data on embryo quality, we were able to control for the number of supernumerary embryos cryopreserved, which has been shown to correlate with embryo quality (27) and number of prior failed IVF cycles. Additionally, the study is limited by the quality of height and weight data entered by clinicians and by the fact that 18% of BMI data are missing.…”