Numbering-up and mass transfer studies of liquid–liquid two-phase microstructured reactors

Kashid, Madhvanand N.; Gupta, Akash K.; Renken, Albert; Kiwi‐Minsker, Lioubov

doi:10.1016/j.cej.2010.01.020

Cited by 206 publications

(134 citation statements)

References 17 publications

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“…Kashid et al (2010) built a microreactor system consisting of six capillaries for liquid-liquid flow. Each liquid was split into six identical streams in a distributor, and each of them was fed to a contacting section equipped with a capillary made of PTFE.…”

Section: Numbering-up Issuementioning

confidence: 99%

Fluid Behavior and Mass Transport Characteristics of Gas–Liquid and Liquid–Liquid Flows in Microchannels

Sotowa

2014

J. Chem. Eng. Japan

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It has been widely recognized that microchannels can be used to enhance mass transfer rate between two immiscible uids. This feature has attracted interests of many researchers in the eld of chemical engineering. To exploit such feature of microchannels, the ow characteristics and mass transfer behavior must be fully understood. In addition, to construct an industrial scale process consisting of microchannels, an e cient numbering-up technique is required. In this review, an overview of the recent literature on the uid ow and mass transfer behavior in multiphase ow in microchannels will be given. An attention is also paid to the numbering-up technique and extension to multiphase system involving three uids.

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Section: Numbering-up Issuementioning

confidence: 99%

Fluid Behavior and Mass Transport Characteristics of Gas–Liquid and Liquid–Liquid Flows in Microchannels

Sotowa

2014

J. Chem. Eng. Japan

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“…Hence, the shear stress destabilizing the interface is much higher in the hydrophobic capillary with the continuous oil phase. Further, the internal circulation in the dispersed phase 29,30 should be more intensive in the system with the continuous oil phase due to the tangential stress balance at the interface. 25 The pressure drops per unit length are 38.4 kPa m À1 and 12.7 kPa m À1 in the 2PO and 2PI arrangements, respectively, see Figure 7.…”

Section: F Interfacial Areamentioning

confidence: 99%

Three-phase slug flow in microchips can provide beneficial reaction conditions for enzyme liquid-liquid reactions

2013

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Here, we introduce a solution to low stability of a two-phase slug flow with a chemical reaction occurring at the phase interface in a microfluidic reactor where substantial merging of individual reacting slugs results in the loss of uniformity of the flow. We create a three-phase slug flow by introducing a third fluid phase into the originally two-phase liquid-liquid slug flow, which generates small two-phase liquid slugs separated by gas phase. Introduction of the third phase into our system efficiently prevents merging of slugs and provides beneficial reaction conditions, such as uniform flow pattern along the whole reaction capillary, interfacial area with good reproducibility, and intensive water-oil interface renewal. We tested the three-phase flow on an enzyme hydrolysis of soybean oil and compared the reaction conversion with those from unstable two-phase slug flows. We experimentally confirmed that the three-phase slug flow arrangement provides conversions and pressure drops comparable or even better with two-phase liquid-liquid arrangements.

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“…132 Numbering-up of microreactors is the most common method to scale the throughput of a single microreactor. 191 Essentially two different methods can be distinguished, i.e. internal and external numbering-up.…”

Section: Scalabilitymentioning

confidence: 99%

Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis

Noël

Hessel

2015

Topics in Organometallic Chemistry

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Flow chemistry is typically used to enable challenging reactions which are difficult to carry out in conventional batch equipment. Consequently, the use of continuous-flow reactors for applications in organometallic and organic chemistry has witnessed a spectacular increase in interest from the chemistry community in the last decade. However, flow chemistry is more than just pumping reagents through a capillary and the engineering behind the observed phenomena can help to exploit the technology's full potential. Here, we give an overview of the most important engineering aspects associated with flow chemistry. This includes a discussion of mass-, heat-, and photon-transport phenomena which are relevant to carry out chemical reactions in a microreactor. Next, determination of intrinsic kinetics, automation of chemical processes, solids handling and multistep reaction sequences in flow are discussed. Safety is one of the main drivers to implement continuous-flow microreactor technology in an existing process and a brief overview is given here as well. Finally, the scale-up potential of microreactor technology is reviewed.

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Numbering-up and mass transfer studies of liquid–liquid two-phase microstructured reactors

Cited by 206 publications

References 17 publications

Fluid Behavior and Mass Transport Characteristics of Gas–Liquid and Liquid–Liquid Flows in Microchannels

Fluid Behavior and Mass Transport Characteristics of Gas–Liquid and Liquid–Liquid Flows in Microchannels

Three-phase slug flow in microchips can provide beneficial reaction conditions for enzyme liquid-liquid reactions

Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis

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