Numbers of regenerating axons in parent and tributary peripheral nerves in the rat

Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo

“…Moreover, we found less regenerating neurons in the retrotracer study than MFs in the histology. Although this results could seem contradictory, it has been reported that neurons initially generate several axonal sprouts after axotomy (Mackinnon et al, 1991), and even at long term each neuron may maintain more than a single regenerated axonal branch (Gómez et al, 1996;Jenq & Coggeshall, 1985). Furthermore, more regenerated axons (sprouts) do not necessarily indicate more neurons regenerating (Piquilloud et al, 2007) and may be also considered deleterious in terms of functional recovery (Guntinas-Lichius et al, 2005).…”

Ablation of Ganglionated Plexi in the Long Term

“…Assuming that there is no damage to nerve cell bodies, such as exist within the atrial neural network after major GP ablation, nerve sprouts can emerge from each parent axon, thereby increasing the total number of axons exceeding the number of parents. 24 The GP ablation studies of Wang et al 1 and the experimental and clinical studies of others have shown: (1) autonomic remodeling in the form of neural plasticity comes from Scherlag Editorial Based on X. Wang et alwithin the atrial neural network in the form of nerve sprouting, reversal of AERP prolongation and rotor and focal source origins of AF initiation and maintenance. 25 Indeed, a recent clinical report detailed previously unrecognized focal firing sources in the left atrial appendage found in 27% of patients having repeat procedures whose AF was successfully ablated by targeting these sites.…”

Regeneration of Unmyelinated Axons After Injury of Mammalian Peripheral Nerve

“…Reliable counts of myelinated axons can be made using high-power light microscopy but an electron microscope is essential for making unmyelinated axon counts. The material must be examined at a high enough magnification so that structures such as collagen pockets can be distinguished from unmyelinated axons (Gamble, 1964), but as long as this is done sampling schemes can be used to make the job more manageable without a significant loss of accuracy or reproducibility (Jenq & Coggeshall, 1985).…”