This work presents a two-dimensional numerical analysis of a wave channel and a oscillating water column (OWC) device. The main goal is to validate a methodology which uses transient velocity data as a means to impose velocity boundary condition for the generation of numerical waves. To achieve this, a numerical wave channel was simulated using regular waves with the same parameters as those used in a laboratory experiment. First, these waves were imposed as prescribed velocity boundary condition and compared with the analytical solution; then, the OWC device was inserted into the computational domain, aiming to validate this methodology. For the numerical analysis, computational fluid dynamics ANSYS Fluent software was employed, and to tackle with water–air interaction, the nonlinear multiphase model volume of fluid (VOF) was applied. Although the results obtained through the use of discrete data as velocity boundary condition presented a little disparity; in general, they showed a good agreement with laboratory experiment results. Since many studies use regular waves, there is a lack of analysis with ocean waves realistic data; thus, the proposed methodology stands out for its capacity of using realistic sea state data in numerical simulations regarding wave energy converters (WECs).