Fluid flow modeling using fuzzy boundary conditions is one of the viable areas in biofluid mechanics, drug suspension in pharmacology, as well as in the cytology and electrohydrodynamic analysis of cerebrospinal fluid data. In this article, a fuzzy solution for the two immiscible fluid flow problems is developed, which is motivated by biomechanical flow engineering. Two immiscible fluids, namely micropolar and Newtonian fluid, are considered with fuzzy boundary conditions in the horizontal channel. The flow is considered unsteady and carried out by applying a constant pressure gradient in the X-direction of the channel. The coupled partial differential equations are modeled for fuzzy profiles of velocity and micro-rotation vectors then the numerical results are obtained by the modified cubic B - spline differential quadrature method. The evolution of membership grades for velocity and microrotation profiles has been depicted with the fuzzy boundaries at the channel wall. It is observed that Micropolar fluid has a higher velocity change than Newtonian fluid, and both profiles indicate a declining nature toward the interface.