Creep tests were conducted on DZ411 material at 930 °C and 850 °C, and creep curves were recorded and employed in normalization creep model building. A yield function suitable for directional solidification nickel-based materials was proposed in an ascending-order approach. Combined with the normalized creep model and the proposed function, a creep subroutine was compiled to simulate the creep deformation behavior of a turbine blade. The typical boundary conditions of the blade were determined and used for finite element analysis. According to the analysis results, the assessment positions for the actual application of a turbine blade were determined and checked for endurance intensity. The phenomenon of deviation angle between crystal axis and blade height direction in actual casting was further analyzed. Multiple angles and directional deviation angles were simulated for 10,000 h creep deformation. Considering the difficulties and challenges of the complex geometric structures of blades, it is necessary to conduct creep tests of DZ411 material and a simulation analysis of a real blade. Based on the above analysis and discussion, the present work sheds light on finite element analysis and has great potential for structural analyses in the engineering applications of complex high-temperature structures.