Numerical analysis of enhanced nano-drug delivery to the olfactory bulb

Vachhani, Shantanu; Kleinstreuer, Clement

doi:10.1080/02786826.2021.1959018

Cited by 2 publications

(2 citation statements)

References 65 publications

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“…Vachhani et al performed a numerical analysis to optimize nanoformulation delivery utilizing a particle release map, which traced particle deposition sites back to the initial injection position [57]. Under normal breathing conditions (5-20 L/min), 100 nm particles achieved 8.7% olfactory deposition within the particle size and deposition ranges of this study.…”

Section: Regional Nasal Deposition Of Aerosolized Gnusmentioning

confidence: 84%

“…The possibility of enhancing the deposition of ultra-small particles in the posterior region of the nasal cavity, where the olfactory region is located, for NTBDD utilizing a pMDI device has not yet been well investigated in vitro. This has become an attractive topic as a computational fluid dynamic model, predicting airflow behaviour and nanoscale aerosol distribution for optimal posterior nasal deposition [56][57][58].…”

Section: Regional Nasal Deposition Of Aerosolized Gnusmentioning

confidence: 99%

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Gold Nanoparticles: Tunable Characteristics and Potential for Nasal Drug Delivery

Maaz,

Blagbrough,

De Bank

2024

Pharmaceutics

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A general procedure to prepare gold nanourchins (GNUs) via a seed-mediated method was followed using dopamine hydrochloride as a reducing agent and silver nitrate salt (AgNO3) as a shape-directing agent. The novelty of this study comes from the successful incorporation of the prepared gold urchins as an aqueous suspension in a nasal pressurized metered dose inhaler (pMDI) formulation and the investigation of their potential for olfactory targeting for direct nose-to-brain drug delivery (NTBDD). The developed pMDI formulation was composed of 0.025% w/w GNUs, 2% w/w Milli-Q water, and 2% w/w EtOH, with the balance of the formulation being HFA134a propellant. Particle integrity and aerosolization performance were examined using an aerosol exposure system, whereas the nasal deposition profile was tested in a sectioned anatomical replica of human nasal airways. The compatibility of the gold dispersion with the nasal epithelial cell line RPMI 2650 was also investigated in this study. Colloidal gold was found to be stable following six-month storage at 4 °C and during the lyophilization process utilizing a pectin matrix for complete re-dispersibility in water. The GNUs were intact and discrete following atomization via a pMDI, and 13% of the delivered particles were detected beyond the nasal valve, the narrowest region in the nasal cavity, out of which 5.6% was recovered from the olfactory region. Moreover, the formulation was found to be compatible with the human nasal epithelium cell line RPMI 2650 and excellent cell viability was observed. The formulated GNU-HFA-based pMDI is a promising approach for intranasal drug delivery, including deposition in the olfactory region, which could be employed for NTBDD applications.

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Section: Regional Nasal Deposition Of Aerosolized Gnusmentioning

confidence: 84%

Section: Regional Nasal Deposition Of Aerosolized Gnusmentioning

confidence: 99%

Gold Nanoparticles: Tunable Characteristics and Potential for Nasal Drug Delivery

Maaz,

Blagbrough,

De Bank

2024

Pharmaceutics

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Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

Akpinar Adscheid,

Türeli,

Günday-Türeli

et al. 2024

Beilstein J. Nanotechnol.

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Central nervous system diseases negatively affect patients and society. Providing successful noninvasive treatments for these diseases is challenging because of the presence of the blood–brain barrier. While protecting the brain’s homeostasis, the barrier limits the passage of almost all large-molecule drugs and most small-molecule drugs. A noninvasive method, nose-to-brain delivery (N2B delivery) has been proposed to overcome this challenge. By exploiting the direct anatomical interaction between the nose and the brain, the drugs can reach the target, the brain. Moreover, the drugs can be encapsulated into various drug delivery systems to enhance physicochemical characteristics and targeting success. Many preclinical data show that this strategy can effectively deliver biopharmaceuticals to the brain. Therefore, this review focuses on N2B delivery while giving examples of different drug delivery systems suitable for the applications. In addition, we emphasize the importance of the effective delivery of monoclonal antibodies and RNA and stress the recent literature tackling this challenge. While giving examples of nanotechnological approaches for the effective delivery of small or large molecules from the current literature, we highlight the preclinical studies and their results to prove the strategies’ success and limitations.

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Numerical analysis of enhanced nano-drug delivery to the olfactory bulb

Cited by 2 publications

References 65 publications

Gold Nanoparticles: Tunable Characteristics and Potential for Nasal Drug Delivery

Gold Nanoparticles: Tunable Characteristics and Potential for Nasal Drug Delivery

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

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