Propeller wake fields in an open-water configuration were compared between two loading circumstances using large-eddy simulation (LES) with a computational domain of 48 million grids and an overset mesh technique. To validate the results of the numerical simulation, available experimental data are compared, which indicates that the grid systems are suitable for the present study. The results indicate that the present LES simulations describe the inertial frequency range well for both high and low-loading conditions. Under high-loading conditions, the interlaced spirals and secondary vortices that connect adjacent tip vortices amplify the effects of mutual inductance, ultimately triggering the breakdown of the propeller wake systems. At a great distance from the propeller, the vortex system loses all coherence and turns into a collection of smaller vortices that are equally scattered across the wake. In contrast, under light-loading conditions, the wake vortex system exhibits strong coherence and has a relatively simple topology. The elliptic instability and pairing processes are only observed at a far distance from the propeller. The convection velocity transferring tip vortices downstream is larger under the light-loading condition, which leads to the larger pitch of the helicoidal vortices. The larger pitch weakens the mutual inductance or interaction effects among tip vortices, which delays the instability behaviors of the whole vortex system. The results and implications of this study serve as a guide for the development and improvement of next-generation propellers that function optimally when operating behind aquaculture vessels.