The safety barrier is often positioned at the entrance of the inlet passage in large and medium-sized low-lift pump stations, to ensure the safety of people and animals. To elucidate the blocking effect of the safety barrier and its influence mechanism on the internal flow of the inlet passage, numerical simulation combined with the physical model test were employed to investigate the impact of the cross-section and bar spacing of the safety barrier on the head loss, and the impact mechanism was clarified. The results showed that the optimal cross-section form of the safety barrier was found to be circular from the standpoint of head loss. When the blockage ratio of the safety barrier exceeds 0.3; prompt clearance of the blockage is recommended.