With urbanization and the rapid development of social economy, China’s rail transit industry has developed rapidly in recent years. In order to alleviate the pressure of road network, subways provide convenience as they are fast and space-saving. Subway stations are major energy consumers of urban power grid due to their large traffic volume and long operation time. On the premise of ensuring operation safety, reducing the energy consumption of subway helps in energy conservation and emission reduction as proposed in the 13th Five-Year Plan. According to the statistics of the energy-saving evaluation report of rail transit engineering, the lighting system accounts for 20%–30% of the total power consumption of the subway station. Due to the single lighting control mode of the lighting system in the subway station, the actual station illumination cannot be reported and adjusted in time, resulting in the waste of lighting energy and high power consumption of the system. Through in-depth research on the intelligent lighting system of subway station, this paper improves the system control, and finally summarizes the optimization scheme of subway station lighting design which can effectively save the power consumption of lighting system. The main contents of this paper are as follows: The research results of this paper can provide effective measures for energy saving of electric lighting in subway stations and reduce electric energy consumption; on the other hand, as an integral part of building lighting energy-saving system, it also has certain guiding significance for the research of building lighting energy-saving.