Amongst solutions to connect the die to the package, thermosonic wire bonding process remains widely used. However, the introduction of low-k dielectric materials, and the feature size decrease of IC chips to follow Moore's law, pose great integration challenge.This paper aims to demonstrate the compliance of the proposed modeling approach with the aids of experimental validations. 3D multi scale simulation of both bonding process and wire pull test is carried out. Using a previously validated homogenization procedure to include pad structure description even at the global scale, stress fields acting in the copper/low-k stack are evaluated. The modeling strategy also includes an in-house developed energy based analysis.For the experimental part, a wide range of wire bond trials have been performed in order to qualify the 65-nm technology node. On behalf of that, several bond pad architectures have been implemented and wire bonded on a test vehicle. It was found a significant effect of the copper/low-k design on peeling failure rates, in particular with severe bonding conditions. In this paper, typical modeling results are presented. Contrary to stress based one, the energy based analysis shows a better ability to forecast the observed failed interface. From simulation results obtained, it is confirmed that the bonding process plays major role in the peeling failure, despite the fact that most of them are observed during the wire pull test. Failure mechanisms are also proposed. Then, the implemented pad structures are evaluated and analyzed. Both general trends and architecture ranking are provided. Simulations are then faced to experimental results and a full agreement is found. The complementary nature of the energy based failure criteria is again highlighted through a clearer discrimination of the tested structures.Finally, the simulation procedure with confirmed experimental results demonstrates its ability in design and process optimizations by providing a better understanding of pad peeling failure mechanisms.