Numerical analysis of ultrasound backscattered waves in cancellous bone using a finite-difference time-domain method: isolation of the backscattered waves from various ranges of bone depths

Hosokawa, Atsushi

doi:10.1109/tuffc.2014.006946

Cited by 13 publications

(16 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This FDTD method suggests that reflection coefficients of fast and slow waves at the boundary between cancellous bone and cortical bone increase with porosity [343]. Finally, this approach has been used to characterize reflected and backscattered waves from cancellous bone [344,345].…”

Section: Simulationsmentioning

confidence: 99%

Mechanisms of Interaction of Ultrasound With Cancellous Bone: A Review

Wear

2020

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

View full text Add to dashboard Cite

Ultrasound is now a clinically-accepted modality in the management of osteoporosis. The most common commercial clinical devices assess fracture risk from measurements of attenuation and sound speed in cancellous bone. This review discusses fundamental mechanisms underlying the interaction between ultrasound and cancellous bone. Because of its two-phase structure (mineralized trabecular network embedded in soft tissue-marrow), its anisotropy, and its inhomogeneity, cancellous bone is more difficult to characterize than most soft tissues. Experimental data for the dependences of attenuation, sound speed, dispersion, and scattering on ultrasound frequency, bone mineral density, composition, microstructure, and mechanical properties are presented. The relative roles of absorption, scattering, and phase cancellation in determining attenuation measurements in vitro and in vivo are delineated. Common speed of sound metrics, which entail measurements of transit times of pulse leading edges (to avoid multipath interference), are greatly influenced by attenuation, dispersion, and system properties including center frequency and bandwidth. However, a theoretical model has been shown to be effective for correction for these confounding factors in vitro and in vivo. Theoretical and phantom models are presented to elucidate why cancellous bone exhibits negative dispersion, unlike soft tissue, which exhibits positive dispersion. Signal processing methods are presented for separating "fast" and "slow" waves (predicted by poro-elasticity theory and supported in cancellous bone) even when the two waves overlap in time and frequency domains. Models to explain dependences of scattering on frequency and mean trabecular thickness are presented and compared with measurements. Anisotropy, the effect of the fluid filler medium (marrow in vivo or water in vitro), phantoms, computational modeling of ultrasound propagation, acoustic microscopy, and nonlinear properties in cancellous bone are also discussed.

show abstract

Section: Simulationsmentioning

confidence: 99%

Mechanisms of Interaction of Ultrasound With Cancellous Bone: A Review

Wear

2020

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

View full text Add to dashboard Cite

show abstract

“…Many applications in engineering, medicine [1], biology, and so on [2] using ultrasound technology in their system for certain purposes. Previous study indicate that, the parameters of fast and slow waves was associate more with the internal structure (microstructure) of the cancellous bone [3][4][5][6][7][8][9] and analysis these waves could improve bone quality estimation via ultrasound. The anisotropy of cancellous bone can affect time domain observation of fast and slow wave and most of the time, these waves overlapped with each other [10].…”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, the TT technique was the only technique which widely used to investigate fast and slow wave. However, it is difficult to perform bone health assessment at specific skeletal part such as hip and backbone, due to the TT technique required a pair (two) of transducers to function [3,13]. Because of that, the pulse echo (PE) evaluation technique is suggested to resolve these complications, since the technique simply uses single transducer, where it much easier to evaluate bone assessment at the hip and backbone.…”

Section: Introductionmentioning

confidence: 99%

“…However, the accuracy of PE technique is still not powerful compared to TT technique because of the complex behavior of reflected and backscattered wave relation with inhomogeneity of cancellous bone. Therefore, using the finite difference time domain simulation (FDTD), Hosokawa demonstrate that, fast and slow wave can be isolated from reflected/backscattered wave and related more with bone porosity and this finding might improve the PE technique for bone quality estimation [3,[13][14][15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Incident and reflected two waves correlation with cancellous bone structure

et al. 2020

View full text Add to dashboard Cite

The correlation in bone microstructure for ultrasound pulse echo technique is still less accurate compared to through transmission technique. Previous works demonstrated, reflected two modes wave has significant association with bone porosity. The paper aims is to conduct simulation using pulse echo technique to examine the relationship between fast and slow waves with porosity of 2-dimensional cancellous bone models by comparing the result to through transmission technique. The "incident" and "reflected" waves were separated using bandlimited deconvolution method by estimating time threshold of fast and slow waves' transfer function. The parameters of the waves were computed, plotted versus porosity for six different thicknesses and the correlation coefficients between them were compared. The incident and reflected fast wave attenuations show marginally significant correlation with porosity for both bone models orientations. Wave propagation for parallel orientation dominated by incident and reflected fast wave, meanwhile, perpendicular orientation dominated by incident slow wave. The thickness factor affected wave amplitude but less affected the attenuation. Because of propagation loss, reflected wave shows lower correlation to porosity compared to incident wave. Hence, analyzing fast and slow waves might improve the measurement accuracy of pulse echo technique compared to using single mode wave to estimate bone quality.

show abstract

“…Examples include BUI use to characterize cervical remodel-ing during pregnancy, bone healing, myocardium after infarct, and liver steatosis. [25][26][27][28][29] Optimization of ultrasonography may be a cost-effective way to repeatedly examine upper airway tissue as part of the longitudinal care of OSA. In this study, the tongue of patients across a wide range of age, body mass index (BMI), and AHI was scanned via a standardized ultrasonography protocol, and analyzed with backscattered imaging, to obtain a predictive model of OSA severity.…”

mentioning

confidence: 99%

Association of Backscattered Ultrasonographic Imaging of the Tongue With Severity of Obstructive Sleep Apnea in Adults

Liu

Bosschieter

Abdelwahab

et al. 2023

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

ImportanceDetermining interventions to manage obstructive sleep apnea (OSA) depends on clinical examination, polysomnography (PSG) results, and imaging analysis. There remains the need of a noninvasive and cost-effective way to correlate relevant upper airway anatomy with severity of OSA to direct treatment and optimize outcome.ObjectiveTo determine whether backscattered ultrasonographic imaging (BUI) analysis of the tongue is associated with severity of OSA in adults.Design, Setting, and ParticipantsIn this prospective, single-center, diagnostic study of a consecutive series of patients (aged ≥18 years) at a sleep surgery clinic, the 89 included patients had a PSG within 3 years at the time of ultrasonography and BUI analysis between July 2020 and March 2022. Patients were excluded if body mass index had changed more than 10% since time of PSG. A standardized submental ultrasonographic scan with laser alignment was used with B-mode and BUI analysis applied to the tongue. The B-mode and BUI intensity were associated with the apnea-hypopnea index (AHI), a measure of severity of apnea from normal (no OSA) to severe OSA.ExposuresUltrasonography and PSG.Main Outcomes and MeasuresThe main outcomes were BUI parameters and their association with AHI value.ResultsEighty-nine patients were included between July 2020 and March 2022. A total of 70 (78.7%) male patients were included; and distribution by race and ethnicity was 46 (52%) White participants, 22 (25%) Asian participants, and 2 (2%) African American participants, and 19 (21%) others. Median (IQR) age was 37.0 (29.0-48.3) years; median (IQR) BMI was 25.3 (23.2-29.8); and median (IQR) AHI was 11.1 (5.6-23.1) events per hour. At the middle to posterior tongue region, the 4 OSA severity levels explained a significant portion of the BUI variance (η2 = 0.153-0.236), and a significant difference in BUI values was found between the subgroups with AHI values of less than 15 (no OSA and mild OSA) and greater than or equal to 15 (moderate OSA and severe OSA) events per hour. The echo intensity showed no significant differences. The BUI values showed a positive association with AHI, with a Spearman correlation coefficient of up to 0.43. Higher BUI values remained associated with higher AHI after correction for the covariates of BMI and age.Conclusions and RelevanceIn this prospective diagnostic study, standardized BUI analysis of the tongue was associated with OSA severity. With the practicality of ultrasonography, this analysis is pivotal in connecting anatomy with physiology in treatment planning for patients with OSA.

show abstract

Numerical analysis of ultrasound backscattered waves in cancellous bone using a finite-difference time-domain method: isolation of the backscattered waves from various ranges of bone depths

Cited by 13 publications

References 46 publications

Mechanisms of Interaction of Ultrasound With Cancellous Bone: A Review

Mechanisms of Interaction of Ultrasound With Cancellous Bone: A Review

Incident and reflected two waves correlation with cancellous bone structure

Association of Backscattered Ultrasonographic Imaging of the Tongue With Severity of Obstructive Sleep Apnea in Adults

Contact Info

Product

Resources

About