Despite the harmfulness of absorbent fouling, its fundamental understanding is limited. The fouling behaviors in fluidized beds charged by CO2 absorbent particles were therefore examined under various physical conditions to identify key parameters that can assist in the direct detection of absorbent fouling. The results demonstrate that the absorbent fouling conditions cooperatively rely on multiple parameters: the cooling water temperature, the riser temperature, and the air velocity, with a minimal impact of the particle type. The physical parameters were found to be vitally correlated with another crucial factor: the relative humidity, implying that modulation of the relative humidity would be essential to prevent absorbent fouling in fluidized beds.