The magnetic fluid seal (MFS) is a new type of sealing method that offers the advantages of no leakage and low wear. Hence, it is widely used in rotary seals in coal, chemical, and electric power fields. However, at high speeds, the degradation and even failure of the sealing performance severely limits the application of MFS in engineering. Therefore, this study designed a combined sealing device comprising a double screw seal and MFS and optimized the pressure resistance of the screw seal using an orthogonal test in combination with the response surface optimization method. Thus, the pressure resistance could be raised to 3.1 times that before optimization. The effect of the sealing gap on the sealing pressure of the MFS was analyzed by numerical simulation, and an optimal sealing gap value of 0.2 mm was obtained. The results of the verification test showed that the performance of the combined seal was significantly better than that of MFS alone. When sealing liquids, the pressure resistance of the combined seal reached 3.3 times that of the MFS at 3000 rpm, which indicates the application potential of MFS in high-speed working conditions.