Numerical approach-based simulation to predict cerebrovascular shear stress in a blood-brain barrier organ-on-a-chip

Jeong, Sehoon; Seo, Jae-Hyeong; Garud, Kunal Sandip; Park, Sung Woo; Lee, Moo‐Yeon

doi:10.1016/j.bios.2021.113197

Cited by 19 publications

(16 citation statements)

References 20 publications

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“…Defining the shear stress in the in vitro models is not evident and needs repetitive experiments. Of interest, a research team was able to predict the shear stress in a BBB microfluidic model with 2.7% error by using Navier-Stokes equations for laminar flows as the governing equations and finite difference methods to approximate the solution ( Jeong et al., 2021 ). The findings of this work provide a valuable tool for optimizing the microfluidic BBB models and determining an in vivo -like shear stress while reducing experiment time and repetitive labor.…”

Section: In Vitro Models Of the Bbbmentioning

confidence: 99%

Vascularizing the brain in vitro

Aazmi

Zhou

et al. 2022

iScience

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Section: In Vitro Models Of the Bbbmentioning

confidence: 99%

Vascularizing the brain in vitro

Aazmi

Zhou

et al. 2022

iScience

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“…Although TEER values and permeability assays are the most used, an in vivo BBB endures many other environmental conditions, including cerebral fluid flow and internal stresses. Jeong et al 76 set the goal of creating a numerical approach-based simulation in order to quantify the shear stresses of the brain utilizing a microfluidic chip. The PDMS microfluidic model consisted of an upper and lower half, with four microchannels in each half.…”

Section: Blood-brain Barrier Modelsmentioning

confidence: 99%

Modeling the blood-brain barrier for treatment of central nervous system (CNS) diseases

2022

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The blood-brain barrier (BBB) is the most specialized biological barrier in the body. This configuration of specialized cells protects the brain from invasion of molecules and particles through formation of tight junctions. To learn more about transport to the brain, in vitro modeling of the BBB is continuously advanced. The types of models and cells selected vary with the goal of each individual study, but the same validation methods, quantification of tight junctions, and permeability assays are often used. With Transwells and microfluidic devices, more information regarding formation of the BBB has been observed. Disease models have been developed to examine the effects on BBB integrity. The goal of modeling is not only to understand normal BBB physiology, but also to create treatments for diseases. This review will highlight several recent studies to show the diversity in model selection and the many applications of BBB models in in vitro research.

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“…According to their model, the carboxylic acid group, polar surface area (PSA)/hydrogen-bonding ability, lipophilicity, and molecular charge play important roles in BBB penetration [42]. However, most results obtained using computation simulation need to be verified by in vivo experiments [45][46][47].…”

Section: Computation Modelsmentioning

confidence: 99%

“…Then PDMS is peeled off to obtain the channels with or without patterns. PDMS, glass, or other silica material can be easily integrated with the culture systems after plasma treatment [47,94]. In addition, PDMS is flexible and can be made into the channels with different 3D structures.…”

Section: Chip Materialsmentioning

confidence: 99%

Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases

Chen

Liu

Muok

et al. 2021

Cells

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The blood–brain barrier (BBB) is a vital structure for maintaining homeostasis between the blood and the brain in the central nervous system (CNS). Biomolecule exchange, ion balance, nutrition delivery, and toxic molecule prevention rely on the normal function of the BBB. The dysfunction and the dysregulation of the BBB leads to the progression of neurological disorders and neurodegeneration. Therefore, in vitro BBB models can facilitate the investigation for proper therapies. As the demand increases, it is urgent to develop a more efficient and more physiologically relevant BBB model. In this review, the development of the microfluidics platform for the applications in neuroscience is summarized. This article focuses on the characterizations of in vitro BBB models derived from human stem cells and discusses the development of various types of in vitro models. The microfluidics-based system and BBB-on-chip models should provide a better platform for high-throughput drug-screening and targeted delivery.

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Numerical approach-based simulation to predict cerebrovascular shear stress in a blood-brain barrier organ-on-a-chip

Cited by 19 publications

References 20 publications

Vascularizing the brain in vitro

Vascularizing the brain in vitro

Modeling the blood-brain barrier for treatment of central nervous system (CNS) diseases

Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases

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