Acoustic sensitivity analysis is an essential technique to determine the direction of structural-acoustic optimization by evaluating the gradient of the objective functions with respect to the design variables. However, acoustic sensitivity analysis with respect to acoustic impedance, which is an important parameter representing the interior absorbent material in automotive acoustics, is lacking in the study. Moreover, acoustic sensitivity analysis implemented with conventional numerical methods is time and effort-consuming in automotive acoustics, due to the large-scale mesh generation. In this work, the impedance sensitivity analysis for automotive acoustics based on the discontinuous isogeometric boundary element method is presented. The regularized boundary integral equation with impedance boundary conditions is established, then the sensitivity is derived by differentiating the boundary integral equation. The efficiency of the proposed method is improved by employing the parallel technique and generalized minimal residual solver. A long duct example with an analytical solution validates the accuracy of the proposed method, and an automotive passenger compartment subjecting to impedance boundary conditions illustrates that the computing time of the proposed method is one order of magnitude less than the conventional method. This work presents an easily implementable and efficient tool to investigate acoustic sensitivity with respect to impedance, showing great potential in the application of automotive acoustics.