The aim of this research is to study the effects of thermal radiation and chemical reaction on hydromagnetic fluid flow in a cylindrical collapsible tube with an obstacle. The fluid flow is governed by continuity, momentum, energy, and concentration equations. Similarity transformation has been used to convert the obtained PDEs into ODEs. The collocation method has been used to numerically solve the ODEs. The method has been implemented in MATLAB using the bvp4c inbuilt function. The effects of the nondimensional parameters on velocity, temperature, and concentration have been presented graphically. Additionally, the skin-friction coefficient, the Nusselt number, and the Sherwood number have been discussed and are presented in a tabular form. The findings demonstrated that increasing the Reynolds number causes a rise in the fluid temperature and velocity. The fluid velocity decreases as the Hartmann number and the weight of the obstacle increase but increases with increasing Grashof numbers. The temperature of the fluid increases as the radiation parameter, or Eckert number, increases, but decreases as the Prandtl number increases. As the Soret number rises, so do the fluid’s temperature and concentration distribution. With an increase in the unsteadiness parameter, the fluid velocity and the concentration distribution decrease, whereas the opposite is seen in temperature. As the Schmidt number, the concentration Grashof number, and the chemical reaction parameter increase, the fluid’s concentration decreases. There is an increase in skin-friction coefficient with increasing Prandtl number, Eckert number, Soret number, thermal Grashof number, concentration Grashof number, thermal radiation parameter, Hartmann number, and unsteadiness parameter, while a decrease is observed with increasing Reynolds number. The Nusselt number increases with an increase in the Prandtl number, Eckert number, thermal radiation parameter, Hartmann number, and unsteadiness parameter. A slight decrease in the Nusselt number has been observed with increasing thermal Grashof number. The Sherwood number decreases with increasing Prandtl number, chemical reaction parameter, and thermal radiation parameter but increases with increasing Schmidt number, Eckert number, and Soret number. The research has the potential for a wide range of applications including but not limited to the medical field and other physical sciences.