Numerical Dosimetry Schemes for the Simulation of Human Exposure to Pulsed High-Power Electromagnetic-Field Sources

Clemens, Markus; Dickmann, Stefan; Ouardi, A. El; Hansen, V.; Schaarschmidt, Martin; Streckert, Joachim; Zhou, Yi

doi:10.1109/tmag.2011.2174044

Cited by 5 publications

(10 citation statements)

References 10 publications

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“…No variation of the relative mean fluorescence intensity as a function of time was observed outside the vessels when compared to non-illuminated samples (Figure 5E). Conversely, dextran leakage is, as expected, observed in the positive control, when permeabilizing electric field (eight square electric pulses, field strength 1300 V/cm, pulse length 100 µs, repetition frequency 1 Hz) is applied, according to the procedure that was previously described [10,11]. * The E-field value is below the ones radiated by the Diehl system; please refer to the discussion section where the underlying technical background is explained in detail.…”

Section: Exposure To Wide-band Signals Generated In Field Experimentsmentioning

confidence: 72%

“…In addition to field experiments, we also conducted laboratory experiments in order to assess potential vessel permeabilization in exposed animals. Intense electric field pulses may increase the permeability of blood vessels [10,17]. While this effect has not been ascertained in vivo [18], it has been suggested that 1.8 GHz GSM-like electromagnetic fields might increase the permeability of the blood-brain barrier in in vitro models [19].…”

Section: Discussionmentioning

confidence: 99%

“…Nine mice underwent DWC surgery. The procedure was performed as previously described [10]. Briefly, surgery was carried out under general anesthesia using intraperitoneal injection of Ketamine (1 mg/mL, MERIAL, Lyon, France) and Xylazine (5 mg/mL, Bayer, Puteaux, France).…”

Section: Dorsal Window Chambers (Dwc) Surgerymentioning

confidence: 99%

“…The superficial tissue was surgically removed, leaving a facial plane with associated vasculature. Ensuing the surgery and the following day, a non-steroidal anti-inflammatory agent (Profenid, Sanofi-Aventis, Paris, France) was injected intramuscularly (10 mg/kg, 50 µL in each thigh), to provide analgesia and to avoid inflammation [10,17].…”

Section: Dorsal Window Chambers (Dwc) Surgerymentioning

confidence: 99%

“…The high molecular weight component was resuspended in PBS at 37.5 mg/mL and used in mice at 3.75 mg/100 µL. Fluorescent dextrans (FDs) were injected in the retro-orbital plexus before illumination to observe any extravasation of FDs into the tissue [10].…”

Section: Exposure To Hpem Signals Generated Within the Dedicated Applicatormentioning

confidence: 99%

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High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization

Kolosnjaj‐Tabi

Golzio

Bellard

et al. 2021

IJMS

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High power radiofrequencies may transiently or permanently disrupt the functioning of electronic devices, but their effect on living systems remains unknown. With the aim to evaluate the safety and biological effects of narrow-band and wide-band high-power electromagnetic (HPEM) waves, we studied their effects upon exposure of healthy and tumor-bearing mice. In field experiments, the exposure to 1.5 GHz narrow-band electromagnetic fields with the incident amplitude peak value level in the range of 40 kV/m and 150 MHz wide-band electric fields with the amplitude peak value in the range of 200 kV/m, did not alter healthy and tumor-bearing animals’ growth, nor it had any impact on cutaneous murine tumors’ growth. While we did not observe any noticeable behavioral changes in mice during the exposure to narrow-band signals when wide-band HPEM signals were applied, mice could behave in a similar way as they respond to loud noise signals: namely, if a mouse was exploring the cage prior to signal application, it returned to companion mates when wide-band HPEM signals were applied. Moreover, the effect of wide-band signals was assessed on normal blood vessels permeability in real-time in dorsal-chamber-bearing mice exposed in a pilot study using wide-band signal applicators. Our pilot study conducted within the applicator and performed at the laboratory scale suggests that the exposure to wide-band signals with the amplitude of 47.5 kV/m does not result in increased vessel permeability.

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Section: Exposure To Wide-band Signals Generated In Field Experimentsmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Dorsal Window Chambers (Dwc) Surgerymentioning

confidence: 99%

Section: Dorsal Window Chambers (Dwc) Surgerymentioning

confidence: 99%

Section: Exposure To Hpem Signals Generated Within the Dedicated Applicatormentioning

confidence: 99%

See 3 more Smart Citations

High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization

Kolosnjaj‐Tabi

Golzio

Bellard

et al. 2021

IJMS

View full text Add to dashboard Cite

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Human effect exposed to UWB signal for WBAN application

Kim

2014

Journal of Electromagnetic Waves and Applications

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Assessment of computational tools for MRI RF dosimetry by comparison with measurements on a laboratory phantom

et al. 2015

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This paper presents an extended comparison between numerical simulations using the different computational tools employed nowadays in electromagnetic dosimetry and measurements of radiofrequency (RF) electromagnetic field distributions in phantoms with tissue-simulating liquids at 64 MHz, 128 MHz and 300 MHz, adopting a customized experimental setup. The aim is to quantify the overall reliability and accuracy of RF dosimetry approaches at frequencies in use in magnetic resonance imaging transmit coils. Measurements are compared against four common techniques used for electromagnetic simulations, i.e. the finite difference time domain (FDTD), the finite integration technique (FIT), the boundary element method (BEM) and the hybrid finite element method-boundary element method (FEM-BEM) approaches. It is shown that FDTD and FIT produce similar results, which generally are also in good agreement with those of FEM-BEM. On the contrary, BEM seems to perform less well than the other methods and shows numerical convergence problems in presence of metallic objects. Maximum uncertainties of about 30% (coverage factor k = 2) can be attributed to measurements regarding electric and magnetic field amplitudes. Discrepancies between simulations and experiments are found to be in the range from 10% to 30%. These values confirm other previously published results of experimental validations performed on a limited set of data and define the accuracy of our measurement setup.

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Numerical Dosimetry Schemes for the Simulation of Human Exposure to Pulsed High-Power Electromagnetic-Field Sources

Cited by 5 publications

References 10 publications

High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization

High Power Electromagnetic Waves Exposure of Healthy and Tumor Bearing Mice: Assessment of Effects on Mice Growth, Behavior, Tumor Growth, and Vessel Permeabilization

Human effect exposed to UWB signal for WBAN application

Assessment of computational tools for MRI RF dosimetry by comparison with measurements on a laboratory phantom

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