Numerical/experimental investigation of the effect of the laser treatment on the thickness distribution of a magnesium superplastically formed part

Cusanno, Angela; Guglielmi, Pasquale; Sorgente, Donato; Palumbo, Gianfranco

doi:10.1007/s40436-024-00497-x

Adv. Manuf.

2024

DOI: 10.1007/s40436-024-00497-x

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Numerical/experimental investigation of the effect of the laser treatment on the thickness distribution of a magnesium superplastically formed part

Angela Cusanno,

Pasquale Guglielmi,

Donato Sorgente

et al.

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Towards Accurate Biocompatibility: Rethinking Cytotoxicity Evaluation for Biodegradable Magnesium Alloys in Biomedical Applications

De Luca,

Ruggiero,

Cordaro

et al. 2024

JFB

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Magnesium and its alloys represent promising candidates for biomedical implants due to their biodegradability and mechanical properties, which are similar to natural bone. However, their rapid degradation process characterized by dynamic pH fluctuations and significant hydrogen gas evolution during biocorrosion adversely affects both in vitro and in vivo assessments. While the ISO 10993-5 and 12 standards provide guidelines for evaluating the in vitro biocompatibility of biodegradable materials, they also introduce testing variability conditions that yield inconsistent results. To address these inherent characteristics of Mg alloys, developing improved methods that accurately simulate the physiological environment for in vitro biocompatibility testing is essential. This study introduces two novel extraction approaches for evaluating Mg alloys: a buffered solution utilizing PBS/DMEM with quaternary dilutions and a modified ISO standard protocol employing decuple dilution of conventional unbuffered extracts. The present findings establish that controlled optimization of extraction conditions, specifically buffer composition and dilution parameters, enables reliable in vitro cytotoxicity assessment of Mg alloys, providing a robust methodology that advances the preclinical evaluation of these promising biodegradable materials.

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Towards Accurate Biocompatibility: Rethinking Cytotoxicity Evaluation for Biodegradable Magnesium Alloys in Biomedical Applications

De Luca,

Ruggiero,

Cordaro

et al. 2024

JFB

View full text Add to dashboard Cite

show abstract

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Numerical/experimental investigation of the effect of the laser treatment on the thickness distribution of a magnesium superplastically formed part

Cited by 1 publication

References 42 publications

Towards Accurate Biocompatibility: Rethinking Cytotoxicity Evaluation for Biodegradable Magnesium Alloys in Biomedical Applications

Towards Accurate Biocompatibility: Rethinking Cytotoxicity Evaluation for Biodegradable Magnesium Alloys in Biomedical Applications

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