This work presents a numerical investigation of turbulent forced convection of a nanofluid over a heated cavity in a horizontal duct. Heat transfers in separated flows are frequently encountered in engineering applications, such as: heat exchangers, axial and centrifugal compressor blades, gas turbines blades, and microelectronic circuit boards. Thus, it is very essential to understand the mechanisms of heat transfer in such regions in order to enhance heat transfer. Different volume fractions of nanoparticles are presented in the base fluid and different types of nanoparticles are used. The objective of this study is to check the effect of nanofluid on heat transfer in such a configuration. Numerical simulations are performed for pure water and four nanofluids (Cu, CuO, Ag, and Al 2 O 3 ). The results are analyzed through the thermal and dynamical fields with a particular interest to the skin friction coefficient and Nusselt number evolutions. The average Nusselt number increases with the volume fraction of nanoparticles for the whole tested range of Reynolds number. A correlation of average Nusselt number versus Reynolds number and volume fraction of each type of nanoparticles over the cavity wall is proposed in this paper. C⃝