Knock is the most crucial limitation in attaining the peak load required at high efficiency in heavy duty (HD) spark ignition (SI) engines. Renewable fuels such as ethanol and methanol have high resistance to autoignition and can help overcome this limitation. To reduce knock and improve efficiency further, dilution can be used to add specific heat capacity and reduce combustion temperature. This work studied diluted combustion and knock characteristics of gasoline, ethanol, and methanol on a HD SI single cylinder engine for a wide load range. Ethanol and methanol displayed excellent knock resistance which allowed a peak gross IMEP of 25.1 and 26.8 bar respectively, compared to gasoline which only reached 8.3 bar at [Formula: see text]1.4 with a compression ratio of 13. Over 18% increase in gross IMEP was possible for gasoline and ethanol when increasing air excess ratio from 1 to 1.4. Methanol achieved the target gross IMEP at [Formula: see text]1 and required no spark retard at [Formula: see text]1.6. A peak indicated efficiency above 48% was recorded for ethanol and methanol at [Formula: see text]1.6 and gross IMEP of approximately 21 bar. At part loads, stable operation was possible until [Formula: see text]1.8 for all fuels. Increase in intake temperature showed a marginal improvement in stability but no increase in lean limit. The concept shows promise as diluted combustion of ethanol and methanol reduced knock and achieved diesel baseline load. With optimization, there is potential to improve efficiency further and possible cost savings compared to commercial diesel engines.