Numerical investigation of magnetic drug targeting using magnetic nanoparticles to the Aneurysmal Vessel

Sharifi, Abbas; Badfar, Homayoun

doi:10.1016/j.jmmm.2018.10.147

Cited by 22 publications

(9 citation statements)

References 26 publications

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“…Equations (38) and (39) show the relationship of Mn F and N with Re, where increasing the magnitude of Magnetic number is the same as lowering the Reynolds number. Hence, the Reynolds number Re is fixed to be Re = 100 throughout the numerical experiment, as varying the value of Mn F and N are sufficient.…”

Section: Dimensionless Parametersmentioning

confidence: 99%

“…In addition, ferrofluid can exhibit non-Newtonian behaviour [26][27][28][29]. However, most of the available works reported only on the effect of FHD on Newtonian fluid [2,23,[30][31][32][33][34][35][36][37][38][39][40][41][42][43]. Even if the magnetic field effect is included in power-law fluid flow, the works only used magnetic field effect of MHD [44][45][46][47][48][49].…”

Section: Introductionmentioning

confidence: 99%

“…Türk et al [36] studied the biomagnetic fluid flow in a channel with multiple stenoses. Flow in aneurysm channel has been studied by Tzirtzilakis [37], and recently by Sharifi et al [38] on drug targeting using magnetic particles. Tzirakis [39] studied biomagnetic fluid flow in circular ducts.…”

Section: Introductionmentioning

confidence: 99%

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Numerical Solution of Biomagnetic Power-Law Fluid Flow and Heat Transfer in a Channel

2020

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The effect of non-Newtonian biomagnetic power-law fluid in a channel undergoing external localised magnetic fields is investigated. The governing equations are derived by considering both effects of Ferrohydrodynamics (FHD) and Magnetohydrodynamics (MHD). These governing equations are difficult to solve due to the inclusion of source term from magnetic equation and the nonlinearity of the power-law model. Numerical scheme of Constrained Interpolation Profile (CIP) is developed to solve the governing equations numerically. Extensive results carried out show that this method is efficient on studying the biomagnetic and non-Newtonian power-law flow. New results show that the inclusion of power-law model affects the vortex formation, skin friction and heat transfer parameter significantly. Regardless of the power-law index, the vortex formation length increases when Magnetic number increases. The effect of this vortex however decreases with the inclusion of power-law where in the shear thinning case, the arising vortex is more pronounced than in the shear thickening case. Furthermore, increasing of power-law index from shear thinning to shear thickening, decreases the wall shear stress and heat transfer parameters. However for high Magnetic number, the wall shear stress and heat transfer parameters increase especially near the location of the magnetic source. The results can be used as a guide on assessing the potential effects of radiofrequency fields (RF) from electromagnetic fields (EMF) exposure on blood vessel.

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Section: Dimensionless Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Numerical Solution of Biomagnetic Power-Law Fluid Flow and Heat Transfer in a Channel

2020

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“…Nanofluid flow via composite stenosis in permeable artery walls was studied by Ellahi et al (2014). Sharifi et al (2019) proposed using nanofluid flow as a means of targeted drug delivery, specifically within aneurysmal blood vessels, by using a magnetic field. Therefore, the improvement of treatment protocols without the occurrence of adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Entropy generation analysis of a ternary hybrid nanofluid (Au-CuO-GO/blood) containing gyrotactic microorganisms in bifurcated artery

Sharma,

Khanduri,

Gandhi

et al. 2024

HFF

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Purpose The purpose of this paper is to study haemodynamic flow characteristics and entropy analysis in a bifurcated artery system subjected to stenosis, magnetohydrodynamic (MHD) flow and aneurysm conditions. The findings of this study offer significant insights into the intricate interplay encompassing electro-osmosis, MHD flow, microorganisms, Joule heating and the ternary hybrid nanofluid. Design/methodology/approach The governing equations are first non-dimensionalised, and subsequently, a coordinate transformation is used to regularise the irregular boundaries. The discretisation of the governing equations is accomplished by using the Crank–Nicolson scheme. Furthermore, the tri-diagonal matrix algorithm is applied to solve the resulting matrix arising from the discretisation. Findings The investigation reveals that the velocity profile experiences enhancement with an increase in the Debye–Hückel parameter, whereas the magnetic field parameter exhibits the opposite effect, reducing the velocity profile. A comparative study demonstrates the velocity distribution in Au-CuO hybrid nanofluid and Au-CuO-GO ternary hybrid nanofluid. The results indicate a notable enhancement in velocity for the ternary hybrid nanofluid compared to the hybrid nanofluids. Moreover, an increase in the Brinkmann number results in an augmentation in entropy generation. Originality/value This study investigates the flow characteristics and entropy analysis in a bifurcated artery system subjected to stenosis, MHD flow and aneurysm conditions. The governing equations are non-dimensionalised, and a coordinate transformation is applied to regularise the irregular boundaries. The Crank–Nicolson scheme is used to model blood flow in the presence of a ternary hybrid nanofluid (Au-CuO-GO/blood) within the arterial domain. The findings shed light on the complex interactions involving stenosis, MHD flow, aneurysms, Joule heating and the ternary hybrid nanofluid. The results indicate a decrease in the wall shear stress (WSS) profile with increasing stenosis size. The MHD effects are observed to influence the velocity distribution, as the velocity profile exhibits a declining nature with an increase in the Hartmann number. In addition, entropy generation increases with an enhancement in the Brinkmann number. This research contributes to understanding fluid dynamics and heat transfer mechanisms in bifurcated arteries, providing valuable insights for diagnosing and treating cardiovascular diseases.

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“…In spite of the considerable application of magnetohydrodynamics, ferrohydrodynamics (FHD) are used in various fields of research and engineering due to some properties such as strong magnetic saturation and poor electrical conductivity of many of nanofluids (Shuchi et al 2005, Mahmoudi et al 2011, Aminfar et al 2011, Sharifi et al 2012, Bahiraei and Hangi 2013. Sharifi et al (2019a) have studied magnetic drug targeting using Ferrofluids to the aneurysmal Vessel. According to their work, three mechanisms could play an important role during the drug presence on the target tissue: formation of a droplet of drug, vortex, and creeping flow in entrance regions of the aneurysm vessel.…”

Section: Introductionmentioning

confidence: 99%

Two-phase modeling of flow control of laminar Fe₃O₄-water nanofluid flow around the cylinder by Kelvin force of wire magnetic field using ferro hydrodynamics principles

Motlagh¹,

Tolouei²,

Tolouei³

2020

Fluid Dyn. Res.

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Controlling the destructive behavior of the wake region and consequently drag reduction are great challenges in fluid mechanics and ocean engineering. In this paper, the effect of the non-uniform magnetic field on controlling the flow and consequently drag reduction has been studied in laminar flow of magnetic nanofluid around a circular cylinder. The source of the magnetic field is a single current-carrying wire located in the center of the cylinder. The nanofluid consists of Fe3O4 as nanoparticles and water as the base flow. The ranges of Reynolds number (Re), volume fraction (ϕ), and the diameters of nanoparticles are 1.6 < Re < 180, 0 < ϕ < 0.04 and 15 < dp < 25, respectively. The modified Buongiorno model that contains the magnetophoresis term is utilized to perform two-phase modeling of magnetic nanofluid flow. Finite volume method and PISO (Pressure-implicit With Splitting Of Operators) algorithm are utilized for the discretization of the governing unsteady equations including conservation laws of mass, volume fraction transport, and momentum equations by considering the ferrohydrodynamics (FHD) force as the source term. The results showed a significant effect of magnetic field intensity and volume fraction on the flow parameters such as drag coefficient, strouhal number, wake length, etc. In general, increasing the magnetic field in various volume fractions and various nanoparticle diameters reduces the amount of drag coefficient. The effective parameters for flow controlling are ordered as follows regarding their effectiveness: magnetic field intensity, volume fraction and diameter of the nanoparticles, respectively.

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Numerical investigation of magnetic drug targeting using magnetic nanoparticles to the Aneurysmal Vessel

Cited by 22 publications

References 26 publications

Numerical Solution of Biomagnetic Power-Law Fluid Flow and Heat Transfer in a Channel

Numerical Solution of Biomagnetic Power-Law Fluid Flow and Heat Transfer in a Channel

Entropy generation analysis of a ternary hybrid nanofluid (Au-CuO-GO/blood) containing gyrotactic microorganisms in bifurcated artery

Two-phase modeling of flow control of laminar Fe₃O₄-water nanofluid flow around the cylinder by Kelvin force of wire magnetic field using ferro hydrodynamics principles

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Numerical investigation of magnetic drug targeting using magnetic nanoparticles to the Aneurysmal Vessel

Cited by 22 publications

References 26 publications

Numerical Solution of Biomagnetic Power-Law Fluid Flow and Heat Transfer in a Channel

Numerical Solution of Biomagnetic Power-Law Fluid Flow and Heat Transfer in a Channel

Entropy generation analysis of a ternary hybrid nanofluid (Au-CuO-GO/blood) containing gyrotactic microorganisms in bifurcated artery

Two-phase modeling of flow control of laminar Fe3O4-water nanofluid flow around the cylinder by Kelvin force of wire magnetic field using ferro hydrodynamics principles

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Two-phase modeling of flow control of laminar Fe₃O₄-water nanofluid flow around the cylinder by Kelvin force of wire magnetic field using ferro hydrodynamics principles