Reaction cross sections for alpha particles have been measured for C, 0, Si, Ca, Ca, 12 16 28~40 48 N Ni Sn, and Pb at 74.5, 103.2, 129.3, 159.7, and 192.7 MeV. The experimental values are found to be considerably smaller than predictions from conventional optical model calculations. PACS number(s): 25.55.Ci, 24.10.Ht