Numerical simulation is used to carry out research on the swirl flow transportation of a hydrate in the pipeline under the condition of the whole rotation of the twist tape using DPM (discrete phase modeling) and RNG (renormalization group) k-ε. The influence of different twist tape parameters on the swirl number and concentration distribution of hydrate particles is analyzed. The structure parameters of the twist tape are optimized, based on the swirl efficiency evaluation parameters of a gas-solid two-phase pipeline. Finally, the twist tape is compared with different working conditions: the local rotation of twist tape and an ordinary pipeline. The results show that the areas of a high concentration of particles are near the twist tapes, and the concentration of particles on the leeward side of the twist tapes is higher than that on the windward side. The minimum concentration area at the axial position gradually increases with the increase of the flow distance, and the hydrate particles do not deposit at the bottom of the whole pipe section. The placement angle of the twist tape is greater, and the particle concentration area near the twist tape is also larger. The best placement angle is 25°. Under the condition of constant swirl strength, the range of the high particle concentration area will not increase indefinitely, and it is constant when the height of the twist tape is D/6 and the optimal height is D/6. There should not be too many twist tapes, as this will affect the carrying effect. The optimal number of twist tapes is three. The particle carrying distance of the local swirl flow generation is about double that of the ordinary pipe. The particle carrying distance of the four twist tape pipes is 3.5 times greater than that of the ordinary pipe. The particle carrying distance of the whole swirl flow generation is 6.6 times higher than that of the ordinary pipe. The particle carrying effect is 89% higher than that of the four twist tape pipes. The particle carrying effect is 230% higher than that of the local swirl flow generation. The particle carrying effect is 560% higher than that of the ordinary pipe.