The present paper introduces a parametric optimization of several Active Flow Control (AFC) parameters applied to a NACA-8412 airfoil at a single post-stall Angle of Attack (AoA) of 15∘ and Reynolds number Re = 68.5×103. The aim is to enhance the airfoil efficiency and to maximize its lift. The boundary layer separation point was modified using Synthetic Jet Actuators (SJA), and the airfoil optimization was carried on by systematically changing the pulsating frequency, momentum coefficient and jet inclination angle. Each case has been evaluated using Computational Fluid Dynamic (CFD) simulations, being the Reynolds Averaged Navier–Stokes equations (RANS) turbulence model employed the Spalart Allmaras (SA) one. The results clarify which are the optimum AFC parameters to maximize the airfoil efficiency. It also clarifies which improvement in efficiency is to be expected under the operating working conditions. An energy balance is presented at the end of the paper, showing that for the optimum conditions studied the energy saved is higher than the one needed for the actuation. The paper clarifies how a parametric analysis has to be performed and which AFC parameters can be initially set as constant providing sufficient previous knowledge of the flow field is already known. A maximum efficiency increase versus the baseline case of around 275% is obtained from the present simulations.