Numerical investigation of topical drug transport in the anterior human eye

Chen, Han; Zhang, Feng; Huang, Yuzhou; Wu, Jonny

doi:10.1016/j.ijheatmasstransfer.2015.01.142

Cited by 21 publications

(11 citation statements)

References 43 publications

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“…Figure 2 shows one half of the cross-section of the 2D human eye model in the XY plane. The geometric dimensions of the constructed eye model are as per standards [8]. To obtaina three-dimensional model, the 2D model of the eye is rotated by an angle of 360⁰ about the X-axis.…”

Section: Geometrymentioning

confidence: 99%

“…The isotropic material properties of the complete eye model are detailed in Table 1. The properties of the human eye are as per standards [8].…”

Section: Materials Propertiesmentioning

confidence: 99%

“…The human eye model is designed using the COMSOL Multiphysics simulation tool and the design is carried out referring to the journals [8][9][10][11][12][13][14][15][16][17][18] and based on the study authors have applied various boundary conditions and constraints on the model. Images are recorded by Corvis tonometer [19] enable to determine the biomechanical parameters of the eye.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of deformation of the cornea during tonometry using FEM

Bharathi¹,

Prabhu²,

Ramesh³

et al. 2020

IJECE

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A three dimensional finite element model of the human eye is developed to evaluate the force which will be applied over the surface of cornea during tonometry and gonioscopy tests. The standard tonometers and gonioscopy experiences deformation from 0.5mm to 3mm of the cornea is adopted during both point contact and boundary contact on the surface of the cornea. The results demonstrate the maximum force experienced by the tonometer with point contact at the center of the cornea for the maximum possible deformation of the cornea during tonometry. The study also analyzes for the force experienced by the tonometer or goniolens with boundary layer contact for the defined deformation of the cornea along the direction from cornea towards the retina.

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Section: Geometrymentioning

confidence: 99%

“…The isotropic material properties of the complete eye model are detailed in Table 1. The properties of the human eye are as per standards [8].…”

Section: Materials Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of deformation of the cornea during tonometry using FEM

Bharathi¹,

Prabhu²,

Ramesh³

et al. 2020

IJECE

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“…Given the difficulties in experimentally analysing AH flow inside ocular cavities and tissues, different computational models have been developed for analysing the influence of AH outflow on IOP, often taking into account only the TM and not the whole anterior section of the eye [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. Analytical and numerical models were developed to understand morphological changes at TM due to IOP and its effects on TM permeability values based on Darcy"s model [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, several numerical heat transfer studies have been carried out to model a laser therapy on eyes and reporting the temperature distributions in different regions of the eye including AC in the absence of TM porous structure [22][23][24]. Eye models comprising both AC and TM have also been developed, demonstrating that porous properties should be taken into account in eye modelling [25][26].…”

Section: Introductionmentioning

confidence: 99%

A generalised porous medium approach to study thermo-fluid dynamics in human eyes

Mauro

Massarotti

Mohamed

et al. 2018

Med Biol Eng Comput

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The present work describes the application of the generalised porous medium model to study heat and fluid flow in healthy and glaucomatous eyes of different subject specimens, considering the presence of ocular cavities and porous tissues. The 2D computational model, implemented into the open-source software OpenFOAM, has been verified against benchmark data for mixed convection in domains partially filled with a porous medium. The verified model has been employed to simulate the thermo-fluid dynamic phenomena occurring in the anterior section of four patient-specific human eyes, considering the presence of anterior chamber (AC), trabecular meshwork (TM), Schlemm's canal (SC), and collector channels (CC). The computational domains of the eye are extracted from tomographic images. The dependence of TM porosity and permeability on intraocular pressure (IOP) has been analysed in detail, and the differences between healthy and glaucomatous eye conditions have been highlighted, proving that the different physiological conditions of patients have a significant influence on the thermo-fluid dynamic phenomena. The influence of different eye positions (supine and standing) on thermo-fluid dynamic variables has been also investigated: results are presented in terms of velocity, pressure, temperature, friction coefficient and local Nusselt number. The results clearly indicate that porosity and permeability of TM are two important parameters that affect eye pressure distribution. Graphical abstract Velocity contours and vectors for healthy eyes (top) and glaucomatous eyes (bottom) for standing position.

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Fish Fin‐Derived Non‐Invasive Flexible Bioinspired Contact Lens for Continuous Ophthalmic Drug Delivery

Li,

Wang

et al. 2024

Advanced Science

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Efficient drug delivery is crucial for glaucoma patients. Flexible biomedical devices that enable sustained ocular drug delivery and can regulate the drug release rate according to physiological conditions are highly desirable for glaucoma treatments, addressing both low drug bioavailability and poor patient compliance from manual drug administration, and improving treatment outcomes. Inspired by the structure and reciprocating motion of fish dorsal fins, a drug‐eluting contact lens based on deformable microstructures for non‐invasive ocular surface drug delivery is developed. Liquid drugs are stored within the interstices of the deformable microstructural units, allowing for continuous drug release through diffusion upon contact with the ocular surface. Finite element analysis is utilized to study the intraocular drug transport dynamics of glaucoma and optimize the overall layout of the device. Microstructural units undergo deformation under loading, altering the interstitial spaces and modulating the drug release rate. This device can adaptively adjust its drug release rate based on changes in intraocular pressure (IOP) and can be proactively regulated in response to cyclic eye loads, accommodating elevated IOP caused by varying body postures and activities. As a flexible, non‐invasive, highly dynamic, and adaptive drug delivery platform, it holds significant potential for future biomedical applications.

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Numerical investigation of topical drug transport in the anterior human eye

Cited by 21 publications

References 43 publications

Investigation of deformation of the cornea during tonometry using FEM

Investigation of deformation of the cornea during tonometry using FEM

A generalised porous medium approach to study thermo-fluid dynamics in human eyes

Fish Fin‐Derived Non‐Invasive Flexible Bioinspired Contact Lens for Continuous Ophthalmic Drug Delivery

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