Numerical investigation of vessel heating using a copper vapor laser and a pulsed dye laser in treating vascular skin lesions

Pushkareva, A. E.; Ponomarev, Igor; Исаев, А. А.; Klyuchareva, S. V.

doi:10.1088/1555-6611/aa8cdb

Cited by 10 publications

(11 citation statements)

References 14 publications

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“…Thermal damage occurs when tissues are exposed to temperatures higher than physiological temperature for extended periods of time. − To evaluate thermal damage on skin tissue in this study, MNs with different amounts of Bi nanodots are used on the skin surface of rats under NIR irradiation (0.4 W/cm 2 ) using conventional hematoxylin and eosin (H&E) staining. , Figure A shows an H&E-stained image of normal skin tissue, revealing the characteristic features of normal dermis stratum. The Bi nanodots used in MNs are varied to determine the effect on skin damage.…”

Section: Results and Discussionmentioning

confidence: 99%

Fabrication of Dissolving Microneedles with Thermal-Responsive Coating for NIR-Triggered Transdermal Delivery of Metformin on Diabetic Rats

Liu

Yang

Jiang

et al. 2018

ACS Biomater. Sci. Eng.

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This study described near-infrared (NIR) light-responsive polymer-nanodot composite microneedles (MNs) used for on-demand transdermal drug delivery. Bismuth (Bi) nanodots stabilized by poly(vinylpyrrolidone) (PVP) as a photothermal conversion agent and metformin as an antidiabetic drug were introduced into the dissolving MNs coated with lauric acid (LA). When the MNs were irradiated with NIR light, light-to-heat transduction induced by the Bi nanodots caused the LA to melt. As a result, the polymer matrix was dissolved after absorbing the interstitial fluid, enabling the encapsulated metformin release from the MNs into skin tissue. Compared with subcutaneous injection of metformin, the administration using the Bi nanodots-induced NIR responsive MNs developed in the current research exhibited a remarkable hypoglycemic effect in vivo. This work indicates that the as-fabricated Bi nanodot-induced NIR responsive and LA-coated MNs have potential applications in diabetes treatment. Additionally, these artificial MNs also present a promising platform for delivering other therapeutic drugs.

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Section: Results and Discussionmentioning

confidence: 99%

Fabrication of Dissolving Microneedles with Thermal-Responsive Coating for NIR-Triggered Transdermal Delivery of Metformin on Diabetic Rats

Liu

Yang

Jiang

et al. 2018

ACS Biomater. Sci. Eng.

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“…[10][11][12] To compare these laser sources, we performed the simulation procedure of the vessel heating by CVL and Nd:YAG laser on the base of the Matlab mathematical simulation software and applications thereof for solving differential equations in the Femlab partial derivatives and using the Finite Element Method as we described in. 17 Figure 4 shows the calculated temperature levels for 9 vessels (3 vessels with a diameter of 30 μm (on the left), 3 vessels with a diameter of 100 μm (in the middle center) and 3 vessels with a diameter of 300 μm (on the right), exposed by CVL and Nd:YAG laser. The vessels of each diameter were assumed to be located at a depth of 150, 500 and 1000 μm respectively.…”

Section: Discussionmentioning

confidence: 99%

Rhinophyma Treatment by Copper Vapor Laser With the Computerized Scanner

et al. 2019

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Introduction: Rhinophyma is recognized as a common and severe skin disease manifested as progressive thickening of the nasal skin due to hypertrophy of the soft tissue. The most severe complication of rhinophyma is telangiectasis. So far the pathogenetic approach for the treatment of rhinophyma should be based on the removal of the dysplastic vessels to provide the appropriate revascularization of the involved skin area. Case Report: This study presented the experience of the treatment of rhinophyma with the copper vapor laser (CVL) designed with the computerized scanner device. A 52-year-old elderly Caucasian male patient with typical clinical signs of rhinophyma was successfully managed during three sessions of CVL treatment. CVL emits light with a wavelength of 578 nm, exposure time of 0.2 seconds. The settings used for the CVL in scanner mode were set at 1.2 W. The scanner device has a hexagonal frame with a maximum width of 12 mm with the distance of 1 mm between centers of laser spots. The CVL treatment resulted in a restoration of the natural appearance of the nose without side effect during 18 months after treatment. Conclusion: The described clinical case demonstrates excellent results of the management of rhinophyma by means of the scanned CVL. CVL treatment was associated with the removal both of dysplastic superficial skin vessels, the solution of the inflammation, decline of the sebum production and the disappearance of the nasal hypertrophy.

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“…This intense short but noxious heat (estimated to be around 60-100°C) may cause coagulation of blood vessels, rupture, and induce subsequent hypoxia. 2,3 The number of treatments needed for remission depends among others on the location, the severity of the lesion, and on how long the lesion has been present. From the literature and our own experience, we contemplate it is possible to clear patients with a fair skin type (Fitzpatrick type I-III) and light to moderate lesion severity after four to six PDL treatments.…”

Section: Prin Ciple S Of S Elec Tively He Ating the Va Scul Ar B Ed B...mentioning

confidence: 99%

“…The selective and rapid absorption of energy by the blood causes heating of haemoglobin, and by diffusion, of the surrounding structures, heating the endothelium and the vascular wall in the (enlarged) papillary dermis for less than a second. This intense short but noxious heat (estimated to be around 60–100°C) may cause coagulation of blood vessels, rupture, and induce subsequent hypoxia 2,3 . The number of treatments needed for remission depends among others on the location, the severity of the lesion, and on how long the lesion has been present.…”

Section: Principles Of Selectively Heating the Vascular Bed By The Ab...mentioning

confidence: 99%

Effects of pulsed dye laser treatment in psoriasis: A nerve‐wrecking process?

Doppegieter

Beek

Bakker

et al. 2023

Experimental Dermatology

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Pulsed dye laser (PDL) therapy can be effective in treating psoriasis, with a long duration of remission. Although PDL therapy, albeit on a modest scale, is being used for decades now, the underlying mechanisms responsible for the long‐term remission of psoriasis remain poorly understood. The selective and rapid absorption of energy by the blood causes heating of the vascular wall and surrounding structures, like perivascular nerves. Several studies indicate the importance of nerves in psoriatic inflammation. Interestingly, denervation leads to a spontaneous remission of the psoriatic lesion. Among all dermal nerves, the perivascular nerves are the most likely to be affected during PDL treatment, possibly impairing the neuro‐inflammatory processes that promote T‐cell activation, expression of adhesion molecules, leukocyte infiltration and cytokine production. Repeated PDL therapy could cause a prolonged loss of innervation through nerve damage, or result in a ‘reset’ of neurogenic inflammation after temporary denervation. The current hypothesis provides strong arguments that PDL treatment affects nerve fibres in the skin and thereby abrogates the persistent and exaggerated inflammatory process underlying psoriasis, causing a long‐term remission of psoriasis.

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Numerical investigation of vessel heating using a copper vapor laser and a pulsed dye laser in treating vascular skin lesions

Cited by 10 publications

References 14 publications

Fabrication of Dissolving Microneedles with Thermal-Responsive Coating for NIR-Triggered Transdermal Delivery of Metformin on Diabetic Rats

Fabrication of Dissolving Microneedles with Thermal-Responsive Coating for NIR-Triggered Transdermal Delivery of Metformin on Diabetic Rats

Rhinophyma Treatment by Copper Vapor Laser With the Computerized Scanner

Effects of pulsed dye laser treatment in psoriasis: A nerve‐wrecking process?

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