Cavitation is typically observed when high-pressure submerged water jets are used. A composite nozzle, based on an organ pipe, can increase shear stress on the incoming flow, significantly enhancing cavitation performance by stacking Helmholtz cavities in series. In the present work, the flow field of the composite nozzle was numerically simulated using Large Eddy Simulation and was paired with the response surface method for global optimizing the crucial parameters of the composite nozzle to examine their effect on cavitation behavior. Utilizing peak gas-phase volume percent as the dependent variable and the runner diameter, Helmholtz chamber diameter, and Helmholtz chamber length as independent variables, a mathematical model was constructed to determine the ideal parameters of the composite nozzle through response surface methodology. The optimized nozzle prediction had an error of only 2.04% compared to the simulation results, confirming the accuracy of the model. To learn more about the cavitation cloud properties, an experimental setup for high-pressure cavitation jets was also constructed. Impact force measurements and high-speed photography tests were among the experiments conducted. The simulated evolution period of cavitation cloud characteristics is highly consistent with the experimental period. In the impact force measurement experiment, the simulated impact force oscillates between 256 and 297 N, and the measured impact force oscillates between 260 N and 289 N, with an error between 1.5% and 2.7%. The simulation model was verified by experimental results. This study provides new insights for the development of cavitation jet nozzle design theory.