For realizing effective vibration excitation and control, a new vortex generator (VG) is proposed. Based on a twostep calculation strategy, the flow-induced vibration responses of the elastic coil pipes (ECPs) when installing the VGs in the heat exchanger (HE) are investigated. In various flow-induced situations, the heat transfer performances (HTPs) of the ECPs are studied. Numerical results demonstrate that the VG installed in HE significantly increases the intensities and uniformity of the vibration, and it greatly improves the HTP of the ECP. Under the action of the VG, vibration of the monitored points has two vibration frequencies, that is, the constant frequency (CF) and the variable frequency (VF). The water inlet velocity does not affect the CF, but it affects the VF. The VF increases when the water inlet velocity increases. In addition, the vibration of the ECP is mainly reflected by the CF, and the vibration form is the out-plane vibration.