There are many pieces of research about driving equations for prediction of the slip factor in centrifugal compressors. Inevitably, some simplifications have been imposed by them on the flow field characteristics and effects of many parameters have been neglected. In this research slip phenomenon is investigated experimentally and numerically in a specific centrifugal compressor with complex blade curves and splitter blades considering the main effective parameters like number of blades, exit angle, etc. Threedimensional simulation of the compressor viscus flow field with suitable turbulence method is performed. Experimental work is carried out at several rotational speeds and mass flow rates slip factor. Effects of main parameters such as rotational speed, mass flow rate, blade number, blade exit angle, diffuser design and tip clearance on slip phenomenon are studied. A variation of performance parameters such as pressure ratio and isentropic efficiency with slip factor are investigated, as well. It is observed that slip factor increases, as rotational speed and flow rate increase. Also changing the blade number from 6 to 9 in constant rotational speed and mass flow rate, causes 27 percent increase in slip factor.