Numerical investigations of various aspects of plaque deposition through constricted artery

Goswami, P.; Mandal, Dipak Kumar; Manna, Nirmal K.; Chakrabarti, Somnath

doi:10.15282/jmes.13.3.2019.07.0433

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…journal.ump.edu.my/jmes ◄ The optimization of the process of clot removal and the geometry of the devices is of paramount importance. For this reason, experiments related to material properties [18], simulation methodologies [19] and nozzle effects [20] have been undertaken. Also, mathematical models have been developed in preliminary studies [21,22] to obtain the appropriate range of different parameters without the need for complex in-vitro or in-vivo experiments.…”

Section: Introductionmentioning

confidence: 99%

Modeling of blood clot removal with aspiration Thrombectomy devices

Romero¹,

Talayero²,

Pearce³

et al. 2020

JMES

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Thrombectomy by aspiration is a highly effective method of accomplishing vessel recanalization. This study aims to obtain a mathematical model that allows the prediction of the dynamic response of a thrombus in response to different suction conditions, in order to avoid potential damage or the breakage of the clot during the interventional procedure. Virtual computing models have been created using Bond-Graph data and mass-spring Multi-Degree of Freedom equations. The model allows the use of tensile and torsion loads that could potentially be generated by the suction pressure together with different catheter geometries. The stress generated in the clot depends on its length and on its stiffness. The results obtained with the mathematical model are validated with a Finite Element Method (FEM) model, shows good agreement in terms of stress and elongation values. The results are consistent with previous Bond Graph models which indicated that the forces needed to extract a blood clot from an artery in in-vitro experiments are within the range used experimentally (~40-90 kPa). Qualitative experiments are undertaken with 3D printed scale prototypes and gelatin. The results are consistent with Computer Fluid Dynamic (CFD) simulations.

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Section: Introductionmentioning

confidence: 99%

Modeling of blood clot removal with aspiration Thrombectomy devices

Romero¹,

Talayero²,

Pearce³

et al. 2020

JMES

View full text Add to dashboard Cite

show abstract

“…In the medical intervention, called thrombectomy, some parameters can be set and affect the efficiency of clot extraction, such as the suction pressure, de size of the catheter, the nozzle (distal end of the catheter) or the distance between the catheter and the blood clot. On the other hand, other parameters related to the patient can also affect efficiency of the thrombectomy: size of the thrombus (length and diameter), the contact area between the thrombus and the artery, or the mechanical properties of the thrombus and the artery, among others [18]. We therefore undertake a Design of Experiments (DOE) to ensure that the correct number of experiments are involved in order to identify the influence of these various factors.…”

Section: Introductionmentioning

confidence: 99%

Thrombectomy aspiration device geometry optimization for removal of blood clots in cerebral vessels

Talayero¹,

Romero²,

Pearce³

et al. 2020

JMES

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A study involving the removal of blood clots in cerebral vessels by aspiration thrombectomy is presented. A robust design for the distal end geometry of a catheter is obtained that, together with adequate suction conditions, could avoid potential damage in the artery or fragmentation the thrombus. The optimization process of the parameters is undertaken by a Design of Experiments (DOE) that has been prepared based on Robust Design theories. In particular, 27 experiments are run for one factor at 9 levels (catheter geometry) and up to 9 factors at 3 levels. The experiments are formulated with virtual models that are solved with computing tools. Co-simulation between Computer Fluid Dynamics (CFD) and Finite Elements Method (FEM) structural analysis was used to obtain the suction conditions and the behavior of the blood clot during the intervention process. By comparing the results of the 27 experiments, the highest values of the suctioning force are obtained for a hole pattern based catheter design, that also gives the lowest risk for clot damage (based on the stress value obtained). Direct aspiration and designs based on conical catheter distal ends, give less robust solutions (results are not stable when the conditions of the environment change). Our study investigated the distance between the catheter and the clot, and it was noted that if the catheter was far from the clot, the suction generated a vessel narrowing and consequent potential damage. Up to 90 kPa could be applied when suctioning at a maximum distance equal to the diameter of the vessel between the distal end of the catheter and the proximal end of the clot. A maximum suctioning force of 0,514N was achieved without damage to the artery or the clot. This research enables us to determine and use the most representative parameters and geometries to be tested in in-vitro and in-vivo experiments. In this virtual study, hypothesizes are assumed with regard to the material properties, but the robustness of the design process allows to expect similar results in future in-vitro and in-vivo tests.

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“…For example, pathological conditions (i.e. diabetes mellitus, sickle cell anemia) may affect blood rheology and impose additional complications to vascular stenosis [25][26][27][28]. Thus, assessing the sensitivity of model predictions to altered blood rheology is potentially of clinical value.…”

Section: Introductionmentioning

confidence: 99%

Computational analysis to predict the effect of pre-bifurcation stenosis on the hemodynamics of the internal and external carotid arteries

Bouteloup¹,

Marinho²,

Chatpun³

et al. 2020

JMES

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This study assessed the hemodynamics of a patient-specific multiple stenosed common carotid artery including its bifurcation into internal and external carotid arteries; ICA and ECA, respectively. A three-dimensional computational model of the common carotid artery was reconstructed using a process of segmentation. Computational fluid dynamics was applied with the assumption that blood is Newtonian and incompressible under pulsatile conditions through the stenotic artery and subsequent bifurcation. Blood was modelled as ‘normal’ and ‘hyperglycaemic’. A region of large recirculation was found to form at bifurcation. The asymmetric velocity flow profile through the ICA was evident through the cardiac cycle with higher velocity at the inner walls of ICA. Hyperglycaemia was found to increase wall shear stresses on the carotid artery and reduce the blood velocity by as much as 4 times in ECA. In conclusion, hemodynamics in ICA and ECA are not equally affected by stenosis, with hyperglycaemic blood potentially providing additional complications to the clinical case.

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Numerical investigations of various aspects of plaque deposition through constricted artery

Cited by 5 publications

References 18 publications

Modeling of blood clot removal with aspiration Thrombectomy devices

Modeling of blood clot removal with aspiration Thrombectomy devices

Thrombectomy aspiration device geometry optimization for removal of blood clots in cerebral vessels

Computational analysis to predict the effect of pre-bifurcation stenosis on the hemodynamics of the internal and external carotid arteries

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