To examine the acousto-structural behavior of a sandwich cylindrical shell benefiting from hexagonal honeycomb structures in its core and functionally graded porous (FGP) layers on its outer and inner surfaces, a comprehensive study based on an analytical model which also considers the effect of an external flow is conducted. A homogenous orthotropic model is used for the honeycomb core while its corresponding material features are found from the modified Gibson’s equation. The distribution pattern of FGP parts is either even or logarithmic-uneven, and a special rule-of-mixture relation governs their properties. Based on the first-order shear deformation theory (FSDT), Hamilton’s principle is exploited to derive the final coupled vibro-acoustic equations, which are then solved analytically to allow us to calculate the amount of sound transmission loss (STL) through the whole structure. This acoustic property is further investigated in the frequency domain by changing a set of parameters, i.e., Mach number, wave approach angle, structure’s radius, volume fraction, index of functionally graded material (FGM), and different honeycomb properties. Overall, good agreement is observed between the result of the present study and previous findings.