Canonical validation of a holistic modeling strategy for the prediction of CO emissions in staged operation of gas turbine combustors is subject of this study. Results from various validation cases are presented. Focus is on operating conditions that can be considered typical for modern, flexible gas turbines that meet the requirements of the upcoming new energy age. Reducing load in gas turbines is usually achieved by redistributing fuel referred to as fuel staging. Fuel-staged operation may lead to various mechanism like strong interaction of the flame with secondary air leading to quenching and elevated CO emissions and is-due to technical relevancestressed in this work. In the recent past, our group published a new modeling strategy for the precise prediction of heat release distributions as well as CO emissions. An extension to the CO modeling strategy that is of high relevance for the introduced validation cases is addressed by this work. The first part of this study presents relevant aspects of the overall modelling strategy. Furthermore, a validation of the models is shown to demonstrate the ability of precisely predicting CO in two different multi-burner cases. Both validation cases feature a silo combustion chamber with 37 burners. The burner groups are switched off at partial load leading to intense interactions between hot and cold burners. Major improvement in comparison to CO predictions from a flamelet-based combustion model can be achieved as the modeling strategy is demonstrated to be capable of predicting global CO emissions accurately. Furthermore, the model's precision in fuel staging scenarios are demonstrated and discussed.