The current trend in solidification research is to develop a generic, energy-efficient, economical, sustainable, and pollution-free technology that can be applied to different alloy systems. Ultrasonic-cavitation melt treatment (UST) is a rather universal technology that can be applied to conventional and advanced metallic materials, regardless of their composition, while being environmentally friendly, cost effective, and ready to be implemented in conventional casting technologies such as direct-chill, continuous, or shape casting, as well as in emerging technologies of additive manufacturing and nanocomposite materials. The beneficial effects of UST-such as in assisted nucleation, activation of substrates (wetting), deagglomeration and fragmentation of solid phases, degassing of the melt, and grain refinement of the as-cast product-stem from the growth, collapse, and implosion of cavitation bubbles as aresult of alternate fluctuations in ultrasonic pressure. Although successfully demonstrated on the laboratory and pilot scale, UST has not yet found widespread industrial implementation. This is mostly due to the lack of in-depth understanding of the fundamental mechanisms behind the improved metal quality and structure refinement. Thus, fundamental research is needed to answer the following practical questions: What is the optimum melt flow rate that maximizes treatment efficiency whilst minimizing input power, cost, and plant complexity? What is the optimum operating frequency and acoustic power that accelerates the treatment effects? What is the optimum location of an ultrasonic power source in the melt transfer system in relation to the melt pool geometry? Answering these questions will pave the way for widespread industrial use of ultrasonic melt processing with the benefit of improving the properties of lightweight structural alloys, simultaneously alleviating the present use of polluting (Cl, F) for degassing or expensive (Zr, Ti, B, Ar) grain refinement additives.