Numerical modelling of cancellous bone damage using an orthotropic failure criterion and tissue elastic properties as a function of the mineral content and microporosity

Ciclope: micro Computed Tomography to Finite Elements

“…Different pipelines for the generation of microFE models of trabecular bone were proposed (Cox et al, 2022;Fernández et al, 2022;Megías et al, 2022;Stauber et al, 2004;Verhulp et al, 2008). Nevertheless, the validation and comparison of results across studies is hindered by the use of proprietary or non-open-source software, and by the general absence of reproducible FE pipelines.…”

Integrated evaluation of biomechanical and biological properties of the biomimetic structural bone scaffold: Biomechanics, simulation analysis, and osteogenesis

“…Human cancellous bone has a unique porous structure pattern with irregular distribution of trabecular thickness and pore size [ 15 , 16 ]. This morphology provides a comprehensive representation of the fluid and solid mechanics, osteogenic response, and bone marrow function.…”

Effect of trabecular architectures on the mechanical response in osteoporotic and healthy human bone

“…Secondly, differences in architectural arrangement lead to difference in bone strength: anisotropy of trabecular structures, trabecular spatial orientation and trabecular thickness are hypothesised to play a crucial role in the determination of mechanical response [4]. Bone mechanical strength at mesoscale is often evaluated experimentally by means of destructive tests, such as reported by Ciarelli et al, Rieger et al and Nikodem [11,17,29,30] and finite element analysis (FEA) [28,31,32]. Ciarelli et al analyse the relation between experimental maximum Young modulus and bone density [29], while Rieger et al investigate the connection between experimental and computational Young modulus values [17].…”

“…Nikodem [11] approaches the study of correlation between experimentally mechanical properties and few morphometric parameters, such as bone density and trabecular thickness, but, in spite of the completeness of the research, a comparison of mutual relationships among morphometric parameters is not deepened. Concerning computational analysis, despite the relevant information obtained from FEA, output of computational models are rarely explained in correlation with bone architectural arrangement [28,31,32].…”