This research investigates the effects of torsional moments on the mechanical behavior of thin-walled open-ended vertical pile foundations subjected to lateral wind loads. The aim of this research is to determine and quantify the errors using traditional design methods and provide more effective alternatives. The warping and torsion effect generated over the piles due to the resultant lateral load impact outside the shear center is analyzed in field tests. Complementarily, a two-dimensional finite element model based on the simple bending stress–strain state, as well as a three-dimensional finite element model considering torsional effects, were implemented and their results analyzed. Finally, a comparative analysis between the in-field lateral loading tests and the finite element model approaches was established by comparing load–displacement curves and using a non-linear Wrinkle model of the soil. Additionally, correlations between the experimental and finite element model errors for the cross-sections pile with a different torsional constant and torsional susceptibility index are shown. From the results, it has been ascertained that the slender thin-walled open-ended pile foundations are particularly sensitive to small load deviations from their center of gravity; this leads to the fact that the slenderer the load and the greater its eccentricity, the more it affects the torsion and warping of the pile. Calculation methodologies usually consider a simple in-plane bending behavior, which leads to errors between 44 and 58% in comparison with the experimental results obtained.