Process intensification (PI) is playing a key role in alleviating the challenge of reducing carbon footprint of many chemical processes and bringing down their development costs. Over the years, many PI technologies have been investigated with rotating packed bed (RPB) technology receiving much of the attention for its potential of significant intensification in terms of capital expenditure, operating costs, and hardware size. In this study, microscale CFD simulations of a rotating packed bed were conducted, and the results were validated with experimental data. The results show the strong relation between the reverse flow at the packing outer periphery and the gas maldistribution factor. The latter is mainly caused by the accelerating flow in the outer cavity. Inside the wire mesh packing, the gas flow is found to be almost fully uniform for nearly half of the total packing depth. Also, turbulent kinetic energy (TKE) levels at the packing outer edge are strongly linked to the slip tangential velocity component, while at its inner edge, they depend mainly on the radial packing velocity. The so-called gas end effect zone is detected by observing the TKE profiles near the packing outer edge. The latter accounts for less than 10% of the total packing depth. The validity of the widely used porous media model in RPBs’ packing for both radial and tangential directions is confirmed by the obtained results, but this excludes the packing inner and outer edges. In the inner cavity region, gas exhibits two distinctive behaviors and transits from free vortex flow to swirling flow as the flow becomes close to the vortex core. As a result of this transition, the increase in shear stress accelerates the decrease in the gas tangential velocity in the vortex core and help speed up the favorable pressure gradient and flow establishment beyond the vortex core.