Numerical Models Can Assist Choice of an Aortic Phantom for In Vitro Testing

Comunale, Giulia; Micco, Luigi Di; Boso, Daniela P.; Susin, Francesca Maria; Peruzzo, Paolo

doi:10.3390/bioengineering8080101

Cited by 5 publications

(13 citation statements)

References 34 publications

(34 reference statements)

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Section: Experimental Set-upmentioning

confidence: 99%

“…Finally, in some further cases the compliance (or the distensibility) is not directly estimated on the prototypes but by increasing/decreasing the internal volume of cylindrical tubes made of the same material as the replica (see, e.g. Biglino et al [20] and Comunale et al [21]).…”

Section: Experimental Set-upmentioning

confidence: 99%

“…This is unfeasible to do, in common practice, without compromising the integrity of the replica Consequently, we here propose an integrated in-vitro/in-silico system to obtain an exhaustive characterization of the mechanical response of the vessel and focus on the loca distensibility of the phantom. For this purpose, we have chosen as a case study the parametrized aortic replica of Comunale et al [21]. The in-vitro measurements are based on a simple and low-cost imaging analysis technique, and the in-silico data are obtained by the FSI technique proposed in the aforementioned paper.…”

Section: Experimental Set-upmentioning

confidence: 99%

“…The production process enabled the prototyping of a transparent phantom as deformable as the healthy aorta (Figure 1). The obtained parametrized geometry was described by Comunale et al [21]. The experimental set-up was composed of the parametrized aortic phantom housed in a suitably designed Pulse Duplicator (PD) able to reproduce the systemic circulation.…”

Section: Experimental Set-upmentioning

confidence: 99%

“…Sparks et al [19] characterized the overall distensibility of the compliant vascular vessels connected to a flow loop system by using intravascular ultrasound. Finally, in some further cases the compliance (or the distensibility) is not directly estimated on the prototypes but by increasing/decreasing the internal volume of cylindrical tubes made of the same material as the replica (see, e.g., Biglino et al [20] and Comunale et al [21]).…”

Section: Introductionmentioning

confidence: 99%

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Distensibility of Deformable Aortic Replicas Assessed by an Integrated In-Vitro and In-Silico Approach

et al. 2022

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The correct estimation of the distensibility of deformable aorta replicas is a challenging issue, in particular when its local characterization is necessary. We propose a combined in-vitro and in-silico approach to face this problem. First, we tested an aortic silicone arch in a pulse-duplicator analyzing its dynamics under physiological working conditions. The aortic flow rate and pressure were measured by a flow meter at the inlet and two probes placed along the arch, respectively. Video imaging analysis allowed us to estimate the outer diameter of the aorta in some sections in time. Second, we replicated the in-vitro experiment through a Fluid-Structure Interaction simulation. Observed and computed values of pressures and variations in aorta diameters, during the cardiac cycle, were compared. Results were considered satisfactory enough to suggest that the estimation of local distensibility from in-silico tests is reliable, thus overcoming intrinsic experimental limitations. The aortic distensibility (AD) is found to vary significantly along the phantom by ranging from 3.0 × 10−3 mmHg−1 in the ascending and descending tracts to 4.2 × 10−3 mmHg−1 in the middle of the aortic arch. Interestingly, the above values underestimate the AD obtained in preliminary tests carried out on straight cylindrical samples made with the same material of the present phantom. Hence, the current results suggest that AD should be directly evaluated on the replica rather than on the samples of the adopted material. Moreover, tests should be suitably designed to estimate the local rather than only the global distensibility.

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Section: Experimental Set-upmentioning

confidence: 99%

Section: Experimental Set-upmentioning

confidence: 99%

Section: Experimental Set-upmentioning

confidence: 99%

Section: Experimental Set-upmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Distensibility of Deformable Aortic Replicas Assessed by an Integrated In-Vitro and In-Silico Approach

et al. 2022

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4D-Flow MRI and Vector Ultrasound in the In-Vitro Evaluation of Surgical Aortic Heart Valves – a Pilot Study

Stephan,

Grefen,

Clevert

et al. 2024

J. of Cardiovasc. Trans. Res.

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Introduction: The aim of this study was the initial investigation of 4D-Flow MRI and Vector Ultrasound as novel imaging techniques in the in-vitro analysis of hemodynamics in anatomical models. Specifically, by looking at the hemodynamic performance of state-of-the-art surgical heart valves in a 3D-printed aortic arch.Methods: The mock circulatory loop simulated physiological, pulsatile flow. Two mechanical and three biological aortic valves prostheses were compared in a 3D-printed aortic arch. 4D magnetic resonance imaging and vector flow Doppler ultrasound served as imaging methods. Hemodynamic parameters such as wall shear stress, flow velocities and pressure gradients were analyzed.Results: The flow analysis revealed characteristic flow-patterns in the 3D-printed aortic arch. The blood-flow in the arch presented complex patterns, including the formation of helixes and vortices. Higher proximal peak velocities and lower flow volumes were found for biological valves.Conclusion: The mock circulatory loop in combination with modern radiological imaging provides a sufficient basis for the hemodynamic comparison of aortic valves. Graphical Abstract

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Computational Modelling and Simulation of Fluid Structure Interaction in Aortic Aneurysms: A Systematic Review and Discussion of the Clinical Potential

et al. 2022

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Aortic aneurysm is a cardiovascular disease related to the alteration of the aortic tissue. It is an important cause of death in developed countries, especially for older patients. The diagnosis and treatment of such pathology is performed according to guidelines, which suggest surgical or interventional (stenting) procedures for aneurysms with a maximum diameter above a critical threshold. Although conservative, this clinical approach is also not able to predict the risk of acute complications for every patient. In the last decade, there has been growing interest towards the development of advanced in silico aortic models, which may assist in clinical diagnosis, surgical procedure planning or the design and validation of medical devices. This paper details a comprehensive review of computational modelling and simulations of blood vessel interaction in aortic aneurysms and dissection, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). In particular, the following questions are addressed: “What mathematical models were applied to simulate the biomechanical behaviour of healthy and diseased aortas?” and “Why are these models not clinically implemented?”. Contemporary evidence proves that computational models are able to provide clinicians with additional, otherwise unavailable in vivo data and potentially identify patients who may benefit from earlier treatment. Notwithstanding the above, these tools are still not widely implemented, primarily due to low accuracy, an extensive reporting time and lack of numerical validation.

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Numerical Models Can Assist Choice of an Aortic Phantom for In Vitro Testing

Cited by 5 publications

References 34 publications

Distensibility of Deformable Aortic Replicas Assessed by an Integrated In-Vitro and In-Silico Approach

Distensibility of Deformable Aortic Replicas Assessed by an Integrated In-Vitro and In-Silico Approach

4D-Flow MRI and Vector Ultrasound in the In-Vitro Evaluation of Surgical Aortic Heart Valves – a Pilot Study

Computational Modelling and Simulation of Fluid Structure Interaction in Aortic Aneurysms: A Systematic Review and Discussion of the Clinical Potential

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