To have a safe structural design, an analysis of the dynamic behavior of a Francis turbine runner with consideration of the added mass effects of surrounding water is necessary during design phase. Both in design and at off-design operations, large-scale forms of attached cavitation may appear on runner blades and can change the added mass effects of the surrounding fluid in relation to a single water domain. Consequently, a numerical investigation of the modal response of a Francis runner has been carried out by reproducing the presence of various sizes of leading edge cavitation (LEC) and trailing edge cavitation (TEC). The fluid–structure interaction problem has been solved by means of an acoustic-structural coupling method. The calculated added mass effects with cavitation have been compared with those corresponding to the pure water condition without cavitation. Firstly, a single blade has been investigated to evaluate the level of significance for the proposed cavity shapes and dimensions. Afterwards, based on the results obtained, the complete runner structure has been considered, factoring in similar cavity shapes and locations. The results prove that significant added mass effects are induced on the entire runner by the attached cavitation that increase the natural frequencies of the first modes. Moreover, the added mass effects increase with cavity size and amplitude of blade deformation below the cavity.