This study examines the effects of Newtonian heating along with heat generation, and thermal radiation on magnetohydrodynamic Casson fluid over a vertical plate. At the boundary, the Newtonian heating phenomena has been employed. The problem is split into two sections for this reason: momentum equation and energy equations. To transform the equations of the given model into dimensionless equations, some particular dimensionless parameters are defined. In this article, generalized Fourier’s law and the recently proposed Caputo Fabrizio fractional operator are applied. The corresponding results of non-dimensional velocity and heat equations can be identified through the application of Laplace transform. Moreover, Tzou’s algorithm as well as Stehfest’s algorithm is implemented to recognize the inverted Laplace transform of heat and momentum equations. Finally, a graphical sketch is created using Mathcad 15 software to demonstrate the results of numerous physical characteristics. It has been reported that the heat and velocity drop with rising Prandtl number values, whereas the fluid’s velocity has been seen to rise with increasing Grashof number values. Additionally, current research has shown that flow velocity and temperature increase with rising values of a fractional parameter.