With the development of computing power, the simulation of circulating fluidized bed (CFB) has developed from riser-simplified simulation to riser-only simulation, then to full-loop simulation. This paper compared these three methods based on pilot-scale CFB experiment data to find the scope of application of each method. All these simulations, using the Eulerian–Eulerian two-fluid model with the kinetic theory of granular theory, were conducted to simulate a pilot-scale CFB. The hydrodynamics, such as pressure balance, solids holdup distribution, solids velocity distribution, and instantaneous mass flow rates in the riser or CFB system, were investigated in different simulations. By comparing the results from different methods, it was found that riser-simplified simulation is not sufficient to obtain accurate hydrodynamics, especially in higher solids circulating rates. The riser-only simulation is able to make a reasonable prediction of time-averaged behaviors of gas–solids in most parts of riser but the entrance region. Further, the full-loop simulation can not only predict precise results, but also obtain comprehensive details and instantaneous information in the CFB system.