Macrosegregation is one of the most significant defects which exert a determining effect on the properties of heavy ingots. The objective of this work is to study the influence of segregated solute elements on the physical and mechanical properties of a medium carbon high strength steel during large ingot casting process. The solidification process of a 20 Metric Tons (MT) ingot is simulated using Thercast ® FEM code. Different segregation levels of solute elements are picked up from a section along the longitudinal axis in the top of the ingot. Input steel data, including physical and mechanical properties, are determined by means of Thermo-Calc ® , JMatPro and a material database. Casting parameters are selected according to actual industrial operational conditions used for casting of large size ingots. Thermic and thermomechanic simulations are employed for calculating the solidification time. Results are analyzed in the framework of diffusion controlled solidification theory and the influence of alloying elements.