Numerical simulation of an atmospheric pressure RF-driven plasma needle and heat transfer to adjacent human skin using <scp>COMSOL</scp>

Schröder, Maximilian; Ochoa, Angel; Breitkopf, Cornelia

doi:10.1116/1.4916929

Cited by 11 publications

(14 citation statements)

References 13 publications

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“…Details of the jet properties and operating conditions used in this paper are listed in appendix B. The considered APPJ configuration has been extensively investigated for biomedical applications [20,35,40], and has been the subject of several modeling studies [21,41,42]. A key challenge in using APPJs for direct plasma treatment (as in figure 1) arises from the high sensitivity of the electrical and thermal characteristics of the plasma jet to variations in the separation distance between the substrate and device [40], as well as variations in the electrical properties of the substrate [20,21].…”

Section: System Descriptionmentioning

confidence: 99%

Effective dose delivery in atmospheric pressure plasma jets for plasma medicine: a model predictive control approach

Gidon

Graves

Mesbah

2017

Plasma Sources Sci. Technol.

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Atmospheric pressure plasma jets (APPJs) have been identified as a promising tool for plasma medicine. This paper aims to demonstrate the importance of using model-based feedback control strategies for safe, reproducible, and therapeutically effective application of APPJs for dose delivery to a target substrate. Key challenges in model-based control of APPJs arise from: (i) the multivariable, nonlinear nature of system dynamics, (ii) the need for constraining the system operation within an operating region that ensures safe plasma treatment, and (iii) the cumulative, nondecreasing nature of dose metrics. To systematically address these challenges, we propose a model predictive control (MPC) strategy for real-time feedback control of a radio-frequency APPJ in argon. To this end, a lumped-parameter, physics-based model is developed for describing the jet dynamics. Cumulative dose metrics are defined for quantifying the thermal and nonthermal energy effects of the plasma on substrate. The closed-loop performance of the MPC strategy is compared to that of a basic proportional-integral control system. Simulation results indicate that the MPC stategy provides a versatile framework for dose delivery in the presence of disturbances, while the safety and practical constraints of the APPJ operation can be systematically handled. Model-based feedback control strategies can lead to unprecedented opportunities for effective dose delivery in plasma medicine.

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Section: System Descriptionmentioning

confidence: 99%

Effective dose delivery in atmospheric pressure plasma jets for plasma medicine: a model predictive control approach

Gidon

Graves

Mesbah

2017

Plasma Sources Sci. Technol.

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“…In order to maximize the efficiency and effectiveness of these treatments and at the same time overcome the mentioned challenges, the contact/mixing between the plasma plume and blood needs to be enhanced dynamically; this requires a versatile multiphysics model for thermofluid analysis of the cold plasmas which has been somehow overlooked in most previous investigations. A parameterized model was set up by Schröder et al [30] to simulate the species densities generated by a plasma needle and also the heat transfer to a skin layer. However, the model developed by Schröder et al did not consider the plasma plume and its transfer to the treatment zone.…”

Section: Introductionmentioning

confidence: 99%

Computational Fluid Dynamics Analysis of Cold Plasma Plume Mixing with Blood Using Level Set Method Coupled with Heat Transfer

Beni

2017

Applied Sciences

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Cold plasmas were proposed for treatment of leukemia. In the present work, conceptual designs of mixing chambers that increased the contact between the two fluids (plasma and blood) through addition of obstacles within rectangular-block-shaped chambers were proposed and the dynamic mixing between the plasma and blood were studied using the level set method coupled with heat transfer. Enhancement of mixing between blood and plasma in the presence of obstacles was demonstrated. Continuous tracking of fluid mixing with determination of temperature distributions was enabled by the present model, which would be a useful tool for future development of cold plasma devices for treatment of blood-related diseases such as leukemia.

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“…Therefore, it is essential that it be kept in use for as long as possible, avoiding frequent prosthesis replacements. 3 From the viewpoint of NTP application in clinic, the types of NTP devices currently existent for biomedical application, such as plasma brushes, 48 plasma jets, 49 plasma pencils, 50 and radio-frequency plasma needles, 51 suggest that it is possible to design and develop a handheld device proper for clinical use in the future. It could be used by clinicians to apply the NTP directly to the ocular prosthesis surface during clinical visits.…”

Section: Discussionmentioning

confidence: 99%

Can Nonthermal Plasma Improve the Adhesion between Acrylic Resin for Ocular Prostheses and Silicone‐Based Relining Material?

Nagay

Goiato

Silva

et al. 2019

Journal of Prosthodontics

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Purpose To investigate the influence of nonthermal plasma (NTP) treatment on the tensile bond strength between heat‐polymerized acrylic resin for ocular prostheses and silicone reliner, with and without the use of an adhesive primer. Materials and Methods One‐hundred and sixty‐four acrylic resin specimens were fabricated and randomly distributed into four groups according to the type of surface treatment: Sofreliner Primer, NTP, Sofreliner Primer + NTP, and NTP + Sofreliner Primer. Two specimens interposed with relining material (Sofreliner) formed one test sample to perform the tensile bond strength tests, before (initial) and after storage (final) in saline solution (37°C, 90 days, n = 10). Surface characterization was performed by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The failure type was classified as cohesive, adhesive, or mixed. The data were analyzed statistically using the two‐way ANOVA and Tukey test, as well as the chi‐squared test (α = 0.05), Bonferroni correction (α = 0.005), and Spearman correlation coefficient (α = 0.05). Results The SEM and EDS analyses showed the presence of a thin, homogenous organic film in the groups treated with NTP. The NTP + Sofreliner Primer group presented the largest bond strength mean values in the initial period (p < 0.05). Sofreliner Primer and NTP + Sofreliner Primer groups presented the first and second largest tensile bond strength mean values in the final period (p < 0.05), respectively. NTP + Sofreliner Primer group also had the largest number of cohesive (70%, initial) and mixed (90%, final) failures. Conclusions The NTP treatment performed before the primer application enhanced the bond between the acrylic resin ocular prosthesis and the Sofreliner silicone‐based reliner, even after 90 days of immersion in saline solution.

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Numerical simulation of an atmospheric pressure RF-driven plasma needle and heat transfer to adjacent human skin using COMSOL

Cited by 11 publications

References 13 publications

Effective dose delivery in atmospheric pressure plasma jets for plasma medicine: a model predictive control approach

Effective dose delivery in atmospheric pressure plasma jets for plasma medicine: a model predictive control approach

Computational Fluid Dynamics Analysis of Cold Plasma Plume Mixing with Blood Using Level Set Method Coupled with Heat Transfer

Can Nonthermal Plasma Improve the Adhesion between Acrylic Resin for Ocular Prostheses and Silicone‐Based Relining Material?

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