Numerical simulation of aortic bifurcation flows: The effect of flow divider curvature

Friedman, Morton H.; Ehrlich, Louis W.

doi:10.1016/0021-9290(84)90001-0

Cited by 35 publications

(12 citation statements)

References 5 publications

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“…At both these locations, the blood flow is redirected generating a resultant force on the arterial wall to balance the change in momentum. Computational studies of flow show that these locations are also characterized by flow separation, altered shear stress, large shear stress gradients and possibly an oscillating separation point [19, 20]. Additional evidence of a link between the formation of aneurysms and hemodynamics is that aneurysms have been found to inadvertently form as a result of surgical alterations of the cerebral blood flow [15].…”

Section: Discussionmentioning

confidence: 99%

A DNA Sequence Polymorphism in the Endoglin Gene Is Not Associated with Intracranial Aneurysm or Aneurysmal Subarachnoid Hemorrhage

Peters

Kassam²,

Chang³

2005

Cerebrovasc Dis

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Background and Purpose: Endoglin is a member of the transforming growth factor β family of proteins and plays a central role in vascular growth and development. There have been conflicting reports that polymorphic variation in the endoglin gene is a risk factor for intracranial aneurysms (IAs). We sought to further investigate the intron 7 5′-TCCCCC-3′ endoglin polymorphism as a risk factor for IA and subarachnoid hemorrhage (SAH) in a population of patients from western Pennsylvania. Methods: We genotyped 98 IA patients and 191 unaffected controls for a length polymorphism in intron 7 using PCR-based methods. Results: The endoglin polymorphism was not associated with IA or the incidence of aneurysm rupture and SAH. No association was found when data were stratified by smoking and hypertension. Conclusion: These data, from a population recruited in western Pennsylvania, support recent findings in Japanese and German populations that, despite earlier observation to the contrary, endoglin is not associated with IA. Furthermore, our study extends previous observations by demonstrating no association between endoglin and either IA or SAH regardless of whether data were stratified for modifiable risk factors such as smoking and hypertension.

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Section: Discussionmentioning

confidence: 99%

A DNA Sequence Polymorphism in the Endoglin Gene Is Not Associated with Intracranial Aneurysm or Aneurysmal Subarachnoid Hemorrhage

Peters

Kassam²,

Chang³

2005

Cerebrovasc Dis

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“…The flow field in the arteries or in the airways is often simulated in different models of either more patient specific character [19,[52][53][54], or in more idealized bifurcation models [40][41][42][55][56][57][58][59]. The attempts to replicate patient anatomy do not necessarily yield more relevant results when it comes to understanding certain more general properties of the flow.…”

Section: Geometrymentioning

confidence: 99%

Pulsating flow and mass transfer in an asymmetric system of bifurcations

2011

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“…The flow field in the arteries is often simulated in different models of either more patient specific character [14,35,36], or in more idealized bifurcation models [37][38][39][40][41][42]. The attempts to replicate patient anatomy do not necessarily lead to more relevant results in terms of understanding certain properties of the flow characteristics.…”

Section: Computational Domain and Boundary Conditionsmentioning

confidence: 99%