An investigation of the fuel heating, vapor formation, and cavitation erosion location patterns inside a five-hole common rail diesel fuel injector, occurring during the early opening period of the needle valve (from 2 μm to 80 μm), discharging at pressures of up to 450 MPa, is presented. Numerical simulations were performed using the explicit density-based solver of the compressible Navier–Stokes (NS) and energy conservation equations. The flow solver was combined with tabulated property data for a four-component diesel fuel surrogate, derived from the perturbed chain statistical associating fluid theory (PC-SAFT) equation of state (EoS), which allowed for a significant amount of the fuel’s physical and transport properties to be quantified. The Wall Adapting Local Eddy viscosity (WALE) Large Eddy Simulation (LES) model was used to resolve sub-grid scale turbulence, while a cell-based mesh deformation arbitrary Lagrangian–Eulerian (ALE) formulation was used for modelling the injector’s needle valve movement. Friction-induced heating was found to increase significantly when decreasing the pressure. At the same time, the Joule–Thomson cooling effect was calculated for up to 25 degrees K for the local fuel temperature drop relative to the fuel’s feed temperature. The extreme injection pressures induced fuel jet velocities in the order of 1100 m/s, affecting the formation of coherent vortical flow structures into the nozzle’s sac volume.