Drying system is the largest energy consumption of equipment parts of solvent-based printing and coating equipment. How to optimize to design the equipment is of the highlights of this research field. According to this demand, a mathematical model of fluid flow of the drying oven is developed. By building a testing platform and using RNG k-epsilon two-equation turbulence model in Fluent Software to analyze three-dimensional impinging jet flow and heat transfer process of hot air drying in conventional drying oven. The results show that the separation of some boundary layers and undesirable swirls, which result in the non-uniform velocity field and temperature field of hot air from nozzles and no promotion to the drying effect, because of unreasonable design of the drying oven.