In this manuscript, a computational paradigm of technique shooting is exploited for investigation of the three-dimensional Eyring-Powell fluid with activation energy over a stretching sheet with slip arising in the field of fluid dynamics. The problem is modeled and resulting nonlinear system of PDEs is transformed into nonlinear system of ODEs using well-known similarity transformations. The strength of shooting based computing approach is employed to analyze the dynamics of the system. The proposed technique is well-designed for different scenarios of the system based on three-dimensional non-Newtonian fluid with activation energy over a stretching sheet. Slip condition is also incorporated to enhance the physical and dynamical analysis of the system. The proposed results are compared with the bvp4C method for the correctness of the solver. Graphical and numerical illustrations are used to envisage the behavior of different proficient physical parameters of interest including magnetic parameter, stretching rate parameter, velocity slip parameter, Biot number on velocity, and Lewis number on temperature and concentration.