Numerical simulation of HIFU with dual transducers: The implementation of dual-phase lag bioheat and non-linear Westervelt equations

Roohi, Reza; Baroumand, Salman; Hosseinie, Radmarz; Ahmadi, Goodarz

doi:10.1016/j.icheatmasstransfer.2020.105002

Cited by 18 publications

(6 citation statements)

References 24 publications

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“…The simulation is performed in two consecutive phases of acoustic pressure and flow field determination. To capture the local fluctuations of the pressure field, the grid sizing for the acoustic simulation should be lowered to about λ /10 (where λ is the wavelength) [43] . A nearly uniform triangular grid is implemented in the entire domain except for PML layers where mapped triangular cell layers are utilized.…”

Section: Methodsmentioning

confidence: 99%

Ultrasound-assisted starch hydrolyzing by alpha-amylase: Implementation of computational fluid dynamics, acoustic field determination, and rheology modeling

Roohi,

Abedi,

Mohammad Bagher Hashemi

2024

Ultrasonics Sonochemistry

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Section: Methodsmentioning

confidence: 99%

Ultrasound-assisted starch hydrolyzing by alpha-amylase: Implementation of computational fluid dynamics, acoustic field determination, and rheology modeling

Roohi,

Abedi,

Mohammad Bagher Hashemi

2024

Ultrasonics Sonochemistry

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“…Implementation of the

transformation, Eq. (14) can be rewritten as:

The oscillations frequency is denoted by

[34] .…”

Section: Methodsmentioning

confidence: 99%

Investigation of ultrasound-assisted starch acetylation by single- and dual- frequency ultrasound based on rheology modelling, non-isothermal reaction kinetics, and flow/acoustic simulation

Abedi,

Roohi,

Hashemi

et al. 2024

Ultrasonics Sonochemistry

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“…Finally, since the computational domain was finite, the perfectly matched layer boundary condition was adopted at the bottom of the petri dish (end surface) to control the acoustic reflections from the end of the domain using artificial absorption (39).…”

Section: Methodsmentioning

confidence: 99%

Experimental and Computational Analysis of HIFU Thermal Ablation in Breast Cancer Cells: Monolayers vs. Spheroids

Badawe,

Harouz,

Abu

et al. 2023

Preprint

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ObjectiveThe primary objective of our study was to investigate the efficiency of high intensity focused ultrasound (HIFU) ablation in two distinct cellular configurations, 2D monolayers and 3D spheroids of epithelial breast cancer cell lines. The study also compares empirical findings from experiments with results obtained through numerical simulations using a bioheat computational model. This comparison is intended to provide a comprehensive understanding of the acoustic energy conversion within the biological system during HIFU treatment.MethodsHIFU was applied to 2D and 3D cultured MDA-MB 231 and MCF7 epithelial breast cancer cell lines while systematically varying ultrasound intensity and duty cycle (DC) during sonication sessions of different durations. Temperature elevation was measured and the ablation percentage was calculated based on bright field and fluorescent imaging of the treated regions. Experimental results were validated through simulations of the ablation setup.ResultsUpon HIFU, spheroids exhibited a lower temperature increase (approximately 20 °C) when subjected to comparable acoustic intensities and duty cycles. The level of tumor ablation was highly influenced by DC, with higher DCs leading to greater ablation percentages. However, sonication duration had a minimal impact on the degree of ablation. Numerical simulations corroborated these observations, demonstrating uniform heat distribution within the cultured cells. At higher DCs and intensities, complete ablation of spheroids was achieved, whereas at lower levels, only the outermost layers exhibited ablation.ConclusionOur study reveals a significant disparity in the response of 2D monolayers and 3D spheroids to HIFU treatment. Specifically, tumor spheroids require lower temperature elevations for effective ablation, and their ablation percentage significantly increases with elevated DC.

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Numerical simulation of HIFU with dual transducers: The implementation of dual-phase lag bioheat and non-linear Westervelt equations

Cited by 18 publications

References 24 publications

Ultrasound-assisted starch hydrolyzing by alpha-amylase: Implementation of computational fluid dynamics, acoustic field determination, and rheology modeling

Ultrasound-assisted starch hydrolyzing by alpha-amylase: Implementation of computational fluid dynamics, acoustic field determination, and rheology modeling

Investigation of ultrasound-assisted starch acetylation by single- and dual- frequency ultrasound based on rheology modelling, non-isothermal reaction kinetics, and flow/acoustic simulation

Experimental and Computational Analysis of HIFU Thermal Ablation in Breast Cancer Cells: Monolayers vs. Spheroids

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