Blade coating is a technique for coating the moving substrate with a protective fluid layer through the blade as a common smoothing device. The heat transfer and slip effects of the rheological Sisko fluid model for plane coater are considered under blade coating process. This model combines the power-law and Newtonian fluids and taken as the limiting behavior of a blade coating in the stiff blade limit. The flow of greases is the most significant example of this type of fluid, which is easily found in nature and has many practical uses. To solve the non-linear expressions, LAT (Lubrication Approximation Theory) is applied, and a shooting technique is used for numerical solutions. The impacts of several parameters on flow characteristics, particularly the velocity ratio K, the Sisko fluid parameter b, the power-law index n, and the slip parameter α are investigated. The effects of both shear-thinning and shear-thickening behaviors are also investigated. The lubrication pressure and temperature increase with the Sisko fluid parameter b and decrease with the slip parameter α. As material parameter b increases from (0.001–1), 20.7% reduction in coating thickness and a 53.2% pressure reduction is noted as compared to the Newtonian case.