Evaluating the burst pressure of corrosion cluster defects necessitates considering the interaction of contiguous defects. The importance of this interaction cannot be emphasized enough, as it plays a crucial role in determining the failure pressure of such pipelines. Current methods for assessing the failure pressure of corrosion cluster defects have drawbacks, including complex evaluation procedures and limited applicability. In this research, the failure mode and location of corrosion clusters with two or more defects are studied with a burst experiment on a full-scaled pipeline. Based on the failure position of the corrosion cluster, a “center failure location” method is proposed to estimate the burst pressure of colony corrosion defects. The method takes the defect in the failure position as the center; the influence of contiguous defects that interact with the central defect on its failure pressure is considered, and subsequently, the burst pressure of colony corrosion centered on the failure location is evaluated. In contrast with the current assessment methods, while the proposed approach does not reduce prediction errors, it requires fewer evaluation conditions and is operationally simpler and more versatile.